D9150
2,3-ジメトキシ-5-メチル-p-ベンゾキノン
apoptosis inducer
別名:
コエンザイムQ0
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この商品について
実験式（ヒル表記法）:
C9H10O4
CAS番号:
分子量:
182.17
UNSPSC Code:
12352204
NACRES:
NA.51
PubChem Substance ID:
EC Number:
210-100-8
Beilstein/REAXYS Number:
1640422
MDL number:
Application
2,3-Dimethoxy-5-methyl-p-benzoquinone has been used:
- as a tau protein fibrillization inducer to determine the regions of tau involved in the formation of paired helical filaments (PHFs)
- as a component in buffer B for cytochrome oxidation assay with subsaturating light
- in the RPMI-1640 medium for 2,3-bis-(2-methoxy-4-nitro-5-sulphenyl)-(2H)-tetrazolium-5-carboxanilide (XTT) assay to quantify antifungal activity
Coenzyme Q0 inhibits (via radical quenching) reactions of gamma-irradiation induced homolytic cleavage of O-glycoside bonds in polysaccharides. Coenzyme Q0 induces apoptosis and modulates the cell cycle in estrogen receptor negative breast cancer cells. It is toxic to other cells such as insulin producing cells.
Biochem/physiol Actions
2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0) interacts with tau protein and aids in the formation of filamentous structure.
General description
2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0 or DMM) is present in all the cells including neural cells.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
In vitro tau fibrillization: mapping protein regions
Santa-Maria I, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1762(7), 683-692 (2006)
The Photosynthetic Bacterial Reaction Center: Structure and Dynamics, 114-114 (2013)
XTT assay of antifungal activity
Loures FV and Levitz SM
PLoS Pathogens, 5(15), e1543-e1543 (2015)
Stanislaw Schmidt et al.
Pathogens (Basel, Switzerland), 8(4) (2019-12-05)
Immunosuppressive drugs are administered to a number of patients; e.g., to allogeneic hematopoietic stem cell transplant recipients. Immunosuppressive drugs impair the immune system and thus increase the risk of invasive fungal disease, but may exhibit antifungal activity at the same
J J Poderoso et al.
Free radical biology & medicine, 26(7-8), 925-935 (1999-05-08)
The reaction of nitric oxide (*NO) with ubiquinol-0 and ubiquinol-2, short-chain analogs of coenzyme Q, was examined in anaerobic and aerobic conditions in terms of formation of intermediates and stable molecular products. The chemical reactivity of ubiquinol-0 and ubiquinol-2 towards
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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