M9651
マプロチリン 塩酸塩
>99% (HPLC), powder
別名:
9-(γ-メチルアミノプロピル)-9,10-ジヒドロ-9,10-エタノアントラセン 塩酸塩
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この商品について
実験式（ヒル表記法）:
C20H23N · HCl
CAS番号:
分子量:
313.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
233-758-8
MDL number:
form
powder
color
white
InChI
1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H
InChI key
NZDMFGKECODQRY-UHFFFAOYSA-N
SMILES string
Cl.CNCCCC12CCC(c3ccccc13)c4ccccc24
assay
>99% (HPLC)
solubility
H2O: 50 mg/mL
originator
Novartis
Quality Level
Gene Information
human ... SLC6A2(6530)
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関連するカテゴリー
Application
Maprotiline hydrochloride has been used as a inhibitor of norepinephrine uptake to study its effects on arresting L3055 cell proliferation.
Biochem/physiol Actions
Maprotiline is a tetracyclic agent. It possesses inhibitory effects against the uptake of norepinephrine by nerve cells. Maprotiline exhibits anti-depressant and sedative activity.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
M9651-1G: + M9651-BULK: + M9651-250MG: + M9651-VAR: + M9651-5G:
jan
E Hösli et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 13(8), 897-908 (1995-12-01)
Autoradiographic studies were made on the uptake of 3H-noradrenaline and 3H-serotonin in explant cultures and primary astrocyte cultures from various regions of rat central nervous system (cortex, cerebellum, locus coeruleus, nucleus raphé, spinal cord). In explant cultures from locus coeruleus
C C Beaufour et al.
Pharmacology, biochemistry, and behavior, 62(4), 591-599 (1999-04-20)
The effects of chronic antidepressants were investigated in an animal procedure for the study of anxiety and anxiolytics, the conditioned suppression of operant behavior in rats. In daily 18-min sessions, three periods of nonpunished lever pressing for food alternated with
The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential antitumor target for psychotropics
Meredith E J, et al.
Faseb Journal, 19(9), 1187-1189 (2005)
Chemistry, pharmacology, pharmacokinetics, adverse effects, and efficacy of the antidepressant maprotiline hydrochloride
Wells B G and Gelenberg A J
Pharmacotherapy, 1(2), 121-138 (1981)
Murat Pinar et al.
Progress in neuro-psychopharmacology & biological psychiatry, 32(1), 135-139 (2007-09-11)
Agents such as clozapine, olanzapine and mirtazapine frequently trigger an increase in body weight. Though the mechanisms have not been thoroughly clarified, recent studies indicate a role for ghrelin in regulation of appetite and weight gain. We investigated the relation
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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