SML0508

Pentostatin

Name: Pentostatin
Brand: SIGMA

≥95% (HPLC), adenosine deaminase inhibitor, powder

別名:

(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin

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この商品について

実験式（ヒル表記法）:

C₁₁H₁₆N₄O₄

CAS番号:

53910-25-1

分子量:

268.27

UNSPSC Code:

12352200

PubChem Substance ID:

329825517

NACRES:

NA.77

主要文書

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製品名

Pentostatin, ≥95% (HPLC)

SMILES string

OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23

InChI

1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

InChI key

FPVKHBSQESCIEP-JQCXWYLXSA-N

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D +70 to +80°, c = 1 in H₂O

storage condition

desiccated

color

white to beige

solubility

H₂O: 10 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Gene Information

human ... ADA(100)

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Application

Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.

Biochem/physiol Actions

Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).

Pentostatin is an immunosuppressant; adenosine deaminase inhibitor; ring-expanded nucleoside (REN).

Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Air sensitve; hygroscopic.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

SML0508-5MG: + SML0508-VAR: + SML0508-BULK: + SML0508-25MG:

jan

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文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson's Disease-Associated SH-SY5Y Cell Model.

Da-Tong Ju et al.

Nutrients, 11(7) (2019-07-25)

Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica plant. In this study, we explored the neuroprotective effect and underlying molecular mechanism of vasicinone against paraquat-induced cellular apoptosis in SH-SY5Y cells. Vasicinone reduced the paraquat-induced loss of cell viability

Bio-based synthesis of Nano-Ceria and evaluation of its bio-distribution and biological properties.

Behrouz Elahi et al.

Colloids and surfaces. B, Biointerfaces, 181, 830-836 (2019-06-30)

Bio-based synthesis of Nano-Ceria (NC) was performed in Linum usitatissimum L. (Lu) seeds extract as capping agent. Obtained gel was calcined at 400, 500, and 600 °C to investigate the effect of temperature on the size and morphology of the particles.

Effects of cyclophosphamide on the phenotypes and functions of THP-1 cells.

Youliang Zhao et al.

Environmental toxicology and pharmacology, 70, 103201-103201 (2019-06-16)

Early and accurate evaluation of immunotoxicity is crucial. However, there are few in vitro models for immunosuppressive evaluation. THP-1 cells has long been used for in vitro sensitivity evaluation. Whether it can be used for immunosuppressive evaluation remains unclear. In

Hairy-cell leukemia: induction of complete remission with pentostatin (2'-deoxycoformycin).

Spiers AS, et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2(12), 1336-1342 (1984)

Possible use of a Nicotiana tabacum 'Bright Yellow 2' cell suspension as a model to assess phytotoxicity of pharmaceuticals (diclofenac).

Lucie Svobodníková et al.

Ecotoxicology and environmental safety, 182, 109369-109369 (2019-06-27)

Growth and developmental changes in plants induced by pharmaceuticals reflect changes in processes at the cellular and subcellular levels. Due to their growth and cellular characteristics, plant cell suspension cultures can be a suitable model for assessing toxicity. In this

資料

Adenosine Receptors

We offers many products related to adenosine receptors for your research needs.

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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Pentostatin

≥95% (HPLC), adenosine deaminase inhibitor, powder

サイズを選択してください

この商品について

主要文書

特性

製品名

SMILES string

InChI

InChI key

assay

form

optical activity

storage condition

color

solubility

shipped in

storage temp.

Quality Level

Gene Information

関連するカテゴリー

詳細

Application

Biochem/physiol Actions

Features and Benefits

Other Notes

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

適用法令

SML0508-5MG: + SML0508-VAR: + SML0508-BULK: + SML0508-25MG:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

プロトコルと関連資料

資料

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