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Merck

SML0508

Pentostatin

≥95% (HPLC), adenosine deaminase inhibitor, powder

別名:

(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin

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この商品について

実験式（ヒル表記法）:
C11H16N4O4
CAS番号:
53910-25-1
分子量:
268.27
UNSPSC Code:
12352200
PubChem Substance ID:
329825517
NACRES:
NA.77

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製品名

Pentostatin, ≥95% (HPLC)

SMILES string

OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23

InChI

1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

InChI key

FPVKHBSQESCIEP-JQCXWYLXSA-N

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D +70 to +80°, c = 1 in H2O

storage condition

desiccated

color

white to beige

solubility

H2O: 10 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Gene Information

human ... ADA(100)

関連するカテゴリー

Application

Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.

Biochem/physiol Actions

Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).
Pentostatin is an immunosuppressant; adenosine deaminase inhibitor; ring-expanded nucleoside (REN).
Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Air sensitve; hygroscopic.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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試験成績書（COA）

Lot/Batch Number
0000404029
0000404027
0000354256
0000354256
0000404027

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Lucie Svobodníková et al.
Ecotoxicology and environmental safety, 182, 109369-109369 (2019-06-27)
Growth and developmental changes in plants induced by pharmaceuticals reflect changes in processes at the cellular and subcellular levels. Due to their growth and cellular characteristics, plant cell suspension cultures can be a suitable model for assessing toxicity. In this
Solid tumor therapy by selectively targeting stromal endothelial cells
Liu S, et al.
Proceedings of the National Academy of Sciences of the USA, 113(28), E4079-E4087 (2016)
Hairy-cell leukemia: induction of complete remission with pentostatin (2'-deoxycoformycin).
Spiers AS, et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2(12), 1336-1342 (1984)
Pentostatin, cyclophosphamide and rituximab is a safe and effective treatment in patients with Waldenstrom?s macroglobulinemia
Herth I, et al.
Leukemia Lymphoma, 56(1), 97-102 (2015)
Youliang Zhao et al.
Environmental toxicology and pharmacology, 70, 103201-103201 (2019-06-16)
Early and accurate evaluation of immunotoxicity is crucial. However, there are few in vitro models for immunosuppressive evaluation. THP-1 cells has long been used for in vitro sensitivity evaluation. Whether it can be used for immunosuppressive evaluation remains unclear. In
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資料

Adenosine Receptors

We offers many products related to adenosine receptors for your research needs.

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