SML0741

ML324

Name: ML324
Brand: SIGMA

≥98% (HPLC)

別名:

N-(3-(Dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide

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この商品について

実験式（ヒル表記法）:

C₂₁H₂₃N₃O₂

CAS番号:

1222800-79-4

分子量:

349.43

NACRES:

NA.77

PubChem Substance ID:

329825592

UNSPSC Code:

12352200

MDL number:

MFCD28053518

主要文書

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InChI

1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)

SMILES string

CN(C)CCCNC(C1=CC=C(C2=CC(O)=C(N=CC=C3)C3=C2)C=C1)=O

InChI key

QDBVSOZTVKXUES-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to light brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

ML324 is a potent JMJD2 demethylase inhibitor that is highly effective in reducing herpes simplex virus (HSV) IE gene expression. ML324 potently blocks the initiation of viral lytic infection and HSV-1 reactivation in the sensory ganglia of latently infected mice.

ML324 is a potent JMJD2 demethylase inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

SML0741-5MG: + SML0741-BULK: + SML0741-25MG: + SML0741-VAR:

jan

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Lot/Batch Number

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特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Identification of a Novel Benzimidazole Pyrazolone Scaffold That Inhibits KDM4 Lysine Demethylases and Reduces Proliferation of Prostate Cancer Cells.

David M Carter et al.

SLAS discovery : advancing life sciences R & D, 22(7), 801-812 (2017-03-28)

Human lysine demethylase (KDM) enzymes (KDM1-7) constitute an emerging class of therapeutic targets, with activities that support growth and development of metastatic disease. By interacting with and co-activating the androgen receptor, the KDM4 subfamily (KDM4A-E) promotes aggressive phenotypes of prostate

Histone Lysine Demethylases of JMJD2 or KDM4 Family are Important Epigenetic Regulators in Reward Circuitry in the Etiopathology of Depression.

Salil Saurav Pathak et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 42(4), 854-863 (2016-10-27)

Major depressive disorder (MDD) is debilitating mental illness and is one of the leading contributors to global burden of disease, but unfortunately newer and better drugs are not forthcoming. The reason is lack of complete understanding of molecular mechanisms underlying

Inhibition of CBP/β-catenin and porcupine attenuates Wnt signaling and induces apoptosis in head and neck carcinoma cells.

Robert Kleszcz et al.

Cellular oncology (Dordrecht), 42(4), 505-520 (2019-05-16)

Activation of the Wnt pathway contributes to the development of head and neck squamous cell carcinomas (HNSCC) and its inhibition has recently emerged as a promising therapeutic strategy. Here, we aimed at identifying suitable molecular targets for down-regulation of canonical

JMJD2 promotes acquired cisplatin resistance in non-small cell lung carcinoma cells.

Lei Duan et al.

Oncogene, 38(28), 5643-5657 (2019-04-11)

Platinum-based drugs such as cisplatin (CP) are the first-line chemotherapy for non-small-cell lung carcinoma (NSCLC). Unfortunately, NSCLC has a low response rate to CP and acquired resistance always occurs. Histone methylation regulates chromatin structure and is implicated in DNA repair.

KDM4A regulates HIF-1 levels through H3K9me3.

Grzegorz Dobrynin et al.

Scientific reports, 7(1), 11094-11094 (2017-09-13)

Regions of hypoxia (low oxygen) occur in most solid tumours and cells in these areas are the most aggressive and therapy resistant. In response to decreased oxygen, extensive changes in gene expression mediated by Hypoxia-Inducible Factors (HIFs) contribute significantly to

資料

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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ML324

≥98% (HPLC)

サイズを選択してください

この商品について

主要文書

特性

InChI

SMILES string

InChI key

assay

form

storage condition

color

solubility

storage temp.

Quality Level

関連するカテゴリー

詳細

Biochem/physiol Actions

Features and Benefits

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

適用法令

SML0741-5MG: + SML0741-BULK: + SML0741-25MG: + SML0741-VAR:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

プロトコルと関連資料

資料

テクニカルサービス