UC211
7-ヒドロキシワルファリン
別名:
3-(α-アセトニルベンジル)-4,7-ジヒドロクマリン, 4-7-ジヒドロキシ-3-(3-オキソ-1-フェニルブチル)-2H-1-ベンゾピラン-2-オン
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この商品について
実験式（ヒル表記法）:
C19H16O5
CAS番号:
分子量:
324.33
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
white
mp
220 °C
solubility
DMSO: soluble
storage temp.
2-8°C
SMILES string
CC(CC(C1=C(O)C(C=CC(O)=C2)=C2OC1=O)C3=CC=CC=C3)=O
InChI
1S/C19H16O5/c1-11(20)9-15(12-5-3-2-4-6-12)17-18(22)14-8-7-13(21)10-16(14)24-19(17)23/h2-8,10,15,21-22H,9H2,1H3
InChI key
SKFYEJMLNMTTJA-UHFFFAOYSA-N
関連するカテゴリー
Application
7-ヒドロキシワルファリンは、(S)-ワルファリンの代謝アッセイに使用できます。
Biochem/physiol Actions
(S)-ワルファリンのCYP2C9 による代謝産物です。
Packaging
底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。
Preparation Note
7-ヒドロキシワルファリンは、DMSOに可溶です。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
UC211-5MG: + UC211-10MG: + UC211-BULK: + UC211-VAR:
jan
D J Black et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(4), 422-428 (1996-04-01)
Consistent with expectations based on human in vitro microsomal experiments, administration of fluconazole (400 mg/day) for 6 days to six human volunteers significantly reduced the cytochrome P450 (P450)-dependent metabolic clearance of the warfarin enantiomers. In particular, P4502C9 catalyzed 6- and
Xuemin Jiang et al.
British journal of clinical pharmacology, 57(5), 592-599 (2004-04-20)
M: The aim of this study was to investigate the effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin. This was an open-label, three-way crossover randomized study in 12 healthy male subjects, who received a
H Takahashi et al.
Journal of chromatography. B, Biomedical sciences and applications, 701(1), 71-80 (1997-12-06)
Enantiomers of warfarin and 7-hydroxywarfarin in human plasma and urine, respectively, were determined by high-performance liquid chromatography using a cellulose-derivative column with UV or fluorescent detection, and their absolute configuration was determined simultaneously by a circular dichroism spectropolarimeter connected in
Masahiro Utoh et al.
Biochemical pharmacology, 95(2), 110-114 (2015-03-25)
Cynomolgus monkeys are widely used as non-human primate species in preclinical studies, due to their close evolutionary relationship to humans. Monkey cytochrome P450 2C19 (formerly known as P450 2C75), highly homologous to human P450 2C19, has been identified to be
Tae Inoue et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2429-2433 (2008-09-12)
Chimeric mice having humanized livers were constructed by transplantation of human hepatocytes. In this study, we investigated whether these mice have a capacity for drug metabolism similar to that of humans by examining hydroxylation of S-warfarin, which is predominantly metabolized
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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