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1118000

USP

クロロキン二リン酸塩

Name: クロロキン 二リン酸塩
Brand: USP

United States Pharmacopeia (USP) Reference Standard

別名:

N⁴-(7-クロロ-4-キノリニル)-N¹,N¹-ジメチル-1,4-ペンタンジアミン二リン酸塩

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この商品について

実験式（ヒル表記法）:

C₁₈H₂₆ClN₃ · 2H₃PO₄

CAS番号:

50-63-5

分子量:

515.86

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329749320

MDL number:

MFCD00069852

Beilstein/REAXYS Number:

4223142

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特性

biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

chloroquine

form

powder

packaging

pkg of 500 mg

manufacturer/tradename

USP

storage condition

protect from light

color

yellow

pH

3.5-4.5 (10% in aqueous solution, pH <6.0)

mp

200 °C (dec.) (lit.)

solubility

water: 50 g/L, benzene: practically insoluble, chloroform: practically insoluble, ethanol: practically insoluble, ether: practically insoluble

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)

InChI key

QKICWELGRMTQCR-UHFFFAOYSA-N

詳細

General description

Chloroquine Phosphate is a salt of chloroquine, a 9-aminoquinoline drug that effectively inhibits viral infections in humans.

Application

Chloroquine phosphate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Amodiaquine Hydrochloride
Amodiaquine Hydrochloride Tablets
Chloroquine
Chloroquine Phosphate
Chloroquine Phosphate Compounded Oral Suspension
Chloroquine Phosphate Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

保管分類

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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試験成績書（COA）

Lot/Batch Number

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プロトコル

Chloroquine Phosphate HPLC Assay & Impurity Profiling

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

Determination of chloroquine and its decomposition products in various brands of different dosage forms by liquid chromatography

Abdelrahman AN, et al.

Journal of Pharmaceutical and Biomedical Analysis, 12(2), 205-208 (1994)

Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition.

Zilong Wang et al.

Brain : a journal of neurology, 144(2), 665-681 (2020-12-29)

Opioids such as morphine are mainstay treatments for clinical pain conditions. Itch is a common side effect of opioids, particularly as a result of epidural or intrathecal administration. Recent progress has advanced our understanding of itch circuits in the spinal

Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.

Cecilia Pessoa Rodrigues et al.

Nature communications, 12(1), 6212-6212 (2021-10-29)

Noncommunicable diseases (NCDs) account for over 70% of deaths world-wide. Previous work has linked NCDs such as type 2 diabetes (T2D) to disruption of chromatin regulators. However, the exact molecular origins of these chronic conditions remain elusive. Here, we identify