OptiScale-Filterkapsulen für aseptische Prozesse
OptiScale® capsules, with a large variety of filtration media options, are a family of convenient, disposable filters ideal for media selection, process screening and scaling.
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FAQ
| Frage | Antwort |
|---|---|
| What is the compatibility of Durapore with high pH solutions? | The upper recommended pH limit for Durapore membranes is 10. At pH >10, the hydrophilization layer of the membrane may become subject to hydrolysis. The extent of hydrolysis is a function of time, temperature , concentration and time of exposure. Upon exposure to high pH, the hydrophylization layer can swell which could result in a loss of permeability or flux. The hydrolysis of the hydrophilic layer will also lead to increased extractables from the membrane. |
| What are Millipore's general recommendations for filtering high pH solutions? | For applications involving pH > 10, Millipore recommends the use or our PES membranes Express SHF or Express SHC. For information on these filters : Express SHF: http://www.millipore.com/catalogue.nsf/docs/C8873 Express SHC: http://www.millipore.com/catalogue.nsf/docs/C9146 |
| How can I differentiate filter plugging due to air bubbles, particulates, surface tension, inappropriate filter size, etc.? | Air locking will occur when filtration is initiated without adequate venting or when air bubbles become trapped in fluid lines. Air will pass easily through a dry hydrophillic or hydrophobic filter. However, when a filter is wet and air is applied to a surface, the air will remain until it is manually moved upstream by venting or until the bubble point of the filter is reached. Bubble point is defined as the pressure at which gas displaces liquid for the largest set of filter pores and is able to flow through the pores. Air locking reduces the effective filtration area of the filter and thus reduces the flow rate. Surface tension refers to the strong cohesive forces present between molecules at the surface of a liquid. The higher the surface tension, the more force is required to force fluid through the membrane.. Innapropriate filter size will can cause a filter to plug prematurely. Filter pore size is chosen based on the application. If the application requires a sterile fluid, than a 0.22 micron membrane would be used for standard solutions that have bacterial bioburden. A 0.1 micron filter would be used for applications where mycoplasma is a concern. Where virus contamination is a concern, ultrafiltration would be required. The selection of a filter pore size that is smaller than that required for the application will cause a decrease in filter capacity and an increase in cost. |
Verwandte Produkte & Anwendungen
Produktfamilien
Sterile gebrauchsfertige Opticap-Kapsulen mit hydrophiler Durapore-MembranSterile Opticap capsule filters are fully contained capsule filters with Durapore 0.22 µm or 0.1 µm hydrophilic PVDF membrane.Weitere Informationen >> |
Multimedia-Sterilfilterelemente mit Durapore-MembranProviding sterility assurance, high flow rates and extended throughputs, low extractables, and broad chemical compatibility.Weitere Informationen >> |
Millipore Express® SHC 0.5/0.2 μm Cartridge FiltersHigh capacity, sterilizing-grade PES filtersWeitere Informationen >> |
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Millipore Express® SHC 0.5/0.2 μm Capsule FiltersMillipore Express® SHC (Sterilizing-grade High Capacity) devices offer high performance and superior economics in a wide variety of sterilizing-grade filtration applications.Weitere Informationen >> |
Optiseal-Filterelemente mit hydrophiler Durapore-Membran, 0,1 µm und 0,22 µmOptiseal cartridge filters feature a revolutionary cartridge-to-housing sealing mechanism and pleated configuration, resulting in maximum sterility assurance and economical performance.Weitere Informationen >> |
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OptiScale-Kapsulen für die Klär- und VorfiltrationThese “drop-in” filter devices, with a variety of media options, create an effective platform for rapidly evaluating biopharmaceuticals.Weitere Informationen >> |
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Millipore Express® SHF 0.2 μm Capsule FiltersOpticap® XL and XLT capsule filters eliminate the time and expense associated with assembling, cleaning, and validating stainless steel housings.Weitere Informationen >> |
Gebrauchsfertige Opticap XL- und XLT-Kapsulen mit hydrophiler Durapore-Membran, 0,1 µm und 0,22 µmSterilizing-grade 0.1 µm and 0.22 µm hydrophilic polyvinylidene fluoride (PVDF) membranes are low protein binding and provide sterility assurance, high flow rates and throughputs.Weitere Informationen >> |
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Millipore Express® SHF Cartridge FiltersHigh flow sterilizing-grade PES filters for validated process stepsWeitere Informationen >> |
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Multilayer Durapore® 0.45/0.22 µm Cartridge FiltersSterilizing grade, hydrophilic Multilayer Durapore 0.45/0.22 µm filters maximize process efficiency by providing high product recovery and extended throughput with low pressure drops.Weitere Informationen >> |
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Gebrauchsfertige Opticap XL Multimedia-Kapsulen mit Durapore-MembranProviding sterility assurance, high flow rates and extended throughputs, low extractables, and broad chemical compatibility.Weitere Informationen >> |
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Gebrauchsfertige Opticap XL- und XLT-Kapsulen mit mehrlagiger Durapore-Membran, 0,45/0,22 µmOpticap XL and XLT capsule filters eliminate the time and expense associated with assembling, cleaning, and validating stainless steel housings.Weitere Informationen >> |
Verwandte Produkte nach: Application Facete
| Antibody Purification |
| Dialysis and Filtration |
Verwandte Produkte nach: Brand Facete
| Optiscale™ |
Kategorien
| Biopharmaceutical Manufacturing > Downstream Processing > Sterile Filtration > Sterile Liquid > Durapore |