Stem Cell Research Antibodies & Assays |
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Stem cells have the unique ability to turn into different tissues of the body based on specific environmental cues exerted upon the cells. The identification of the key proteins involved in maintaining stem cell identity and functional have been critical to understand stem cell biology. Key transcription factors such as Oct-4, Nanog and Sox-2 are critical in maintaining embryonic and induced pluripotent stem cells in their pluripotent state. Upon differentiation, many of these pluripotency genes are downregualted while other differentiated markers are upregulated depending on the local environmental cues. Understanding what causes these changes is the key to understanding stem cell biology. Merck is committed to providing validated stem cell antibodies for common and novel protein targets which are related to all areas of stem cell biology. From pluripotent stem cells to neural and mesenchymal stem cells, antibodies exist in various formats for each target, validated in different research applications and cited in many publications.
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Featured Product:Anti-Oct-4, clone 10H11.2 |
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 Octamer-4 (Oct-4), a member of the POU family of transcription factors, has been demonstrated to be vital for the formation of self-renewing pluripotent stem cells. During embryogenesis expression of Oct-4 is limited to pluripotent cells of the inner cell mass (ICM) that contribute to the formation of all fetal cell types.
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Primary Stem Cell Antibodies
Merck offers a wide range of validated antibodies to many of the most commonly studied proteins in stem cell biology. Rely on the expertise of Chemicon and Upstate to advance your stem cell research today.| Oct-4 | TRA Family |
| Sox Family | SSEA Family |
| Wnt Family | Nestin |
| Nanog | Human Nuclei |
| Lin-28 | Human Mitochondria |
Stem Cell Antibody Conjugates
Merck offers stem cell conjugates for some of the most popular stem cell markers in various formats including AlexaFluor-488, CY3, FITC and PE conjugated antibodies. “FlowCellect” antibodies have been validated and are pre-diluted to work in flow cytometry applications. Other non “FlowCellect” antibody conjugates have been validated for Immunocytochemistry. All conjugates maintain their antigen specificities while eliminating the use of cumbersome secondary antibodies. Rely on the conjugated forms of these antibodies to collapse the experimental workflow and save time and money.