Scale-up of high area filters - 5 Part Vodcast Series
Learn how to reliably scale up your filter application using high area filters with our 5-part vodcast series.
Accurate scaling requires a scaling tool that is designed to measure the intrinsic filtration performance of the membrane. The membrane used in the scaling tool should be representative of the typical performance expected in large scale devices.
Scale up of high area filters: Small-scale scaling tool
In Part 1 of our vodcast series, “Scale up of High Area Filters for Microfiltration of Biological Fluids,” the design and function of the small scale scaling tool is discussed.
Scale up of high area filters: External pressure losses and process variability
In Part 2, “Scale up of High Area Filters for Microfiltration of Biological Fluids,” we provide guidance on how to ensure accurate, reliable scaling from disc to device. We focus on non-membrane pressure losses and variability in process conditions.
Scale-up of high area filters: Device design and pleat hydrodynamics
In Part 3, “Scale up of High Area Filters for Microfiltration of Biological Fluids,” we take a look at device design and pleat hydrodynamics; two important considerations in filter sizing.
Scale-up of high area filters: Impact of fouling mechanisms
In Part 4, “Scale up of High Area Filters for Microfiltration of Biological Fluids,” we discuss the impact of fouling mechanisms on scalability. Fouling mechanisms can be an important scaling consideration, especially for high area devices. If caking is found to be a predominant fouling mechanism, prefiltration should be considered to remove large particles which will result in improved scalability.
Scale up of high area filters: Summarizing the essential elements of reliable scaling
In Part 5, “Scale up of High Area Filters for Microfiltration of Biological Fluids,” we highlight how all the elements of scaling are incorporated for reliable filter sizing. Accurate scaling from discs to pleated devices is possible with the use of good scaling tools and proper accounting of the important factors that can impact permeability and throughput performance. High area pleated devices are advantageous in terms of filtration economics and footprint, but the benefit may be dependent on the plugging characteristic of the stream. In addition, a theoretical understanding and modeling of device flow hydrodynamics and membrane fouling mechanisms facilitates reliable sizing of filtrations systems.