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Visit us in Lyon, France

Meet our team at the 2018 ISPE
Europe Biotechnology Conference

September 20-21, 2018 in Lyon, France

Vibrant M Merck

Next Generation Bioprocessing is considered to be any technology, expendable, or system which significantly changes the existing monoclonal antibody manufacturing template to deliver higher productivity, increased manufacturing flexibility, increased speed, and reduced risk.

Meet our expert to get insights and perspectives on the on-going paradigm shift and evolution towards Next Generation Bioprocessing occurring in today’s and tomorrow’s biopharmaceutical landscape.

Explore what's next at Merck!

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Mercrobe Merck

Mark your calendar! You don’t want to miss our expert speaker!

Thursday, September 20th

Track 2: Integrated Processing and Novel Development Strategies
  (Predictive Models, PAT, Continuous Processing, Single-use Systems)
10:45 - 11:15Intensification of Monoclonal Antibody Platform processing: A case-study on “Inline flocculation for harvest clarification”
 Paul Kaschutnig, EMEA Process Development Scientist, Merck

Flocculation are recently being accepted in the mAb platform process to deal with high cell densities coming out of the bioreactor. It brings increased throughput, reduces turbidity and enhances impurity removal. We will show how even more efficient clarification process can be designed by applying in-line flocculation.

This approach addresses certain facility constraints in a GMP manufacturing.


The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada.