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681641 Wee1 Inhibitor II - CAS 622855-50-9 - Calbiochem

The Wee1 Inhibitor II, also referenced under CAS 622855-50-9, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione

Primary Target: Wee1
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681641
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
622855-50-9C₂₄H₁₉ClN₂O₃

Precios y disponibilidad

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681641-1MG
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      Description
      OverviewA pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 35 µM).
      Catalogue Number681641
      Brand Family Calbiochem®
      Synonyms6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
      References
      ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
      Product Information
      CAS number622855-50-9
      ATP CompetitiveN
      FormBrown solid
      Hill FormulaC₂₄H₁₉ClN₂O₃
      Chemical formulaC₂₄H₁₉ClN₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetWee1
      Primary Target IC<sub>50</sub>59 nM against Wee1
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      681641-1MG 04055977260199

      Documentation

      Wee1 Inhibitor II - CAS 622855-50-9 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Wee1 Inhibitor II - CAS 622855-50-9 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      681641

      Referencias bibliográficas

      Visión general referencias
      Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione
      DescriptionA pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 35 µM).
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number622855-50-9
      Chemical formulaC₂₄H₁₉ClN₂O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPalmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.