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203729 (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem

(+)-Brefeldin A, Eupenicillium brefeldianum, CAS 20350-15-6, specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one

Primary Target: Blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      20350-15-6C₁₆H₂₄O₄
      Description
      OverviewSpecifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO (Cat. No. 500583).
      Catalogue Number203729
      Brand Family Calbiochem®
      Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
      References
      ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
      Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Ridgway, N.D., et al. 1995. J. Biol. Chem. 270, 8023.
      Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
      Ktistakis, N.Y., et al. 1992. Nature 356, 344.
      Product Information
      CAS number20350-15-6
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₁₆H₂₄O₄
      Chemical formulaC₁₆H₂₄O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Application(+)-Brefeldin A, Eupenicillium brefeldianum, CAS 20350-15-6, specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus.
      Biological Information
      Primary TargetBlocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGY8410000
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      203729 0

      Documentation

      (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem Analysenzertifikate

      TitelChargennummer
      203729

      Literatur

      Übersicht
      Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
      Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Ridgway, N.D., et al. 1995. J. Biol. Chem. 270, 8023.
      Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
      Ktistakis, N.Y., et al. 1992. Nature 356, 344.

      Literaturstellen

      Titel
    • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
      		•
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-August-2009 RFH
      Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
      DescriptionSpecifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange.
      FormWhite crystalline solid
      CAS number20350-15-6
      RTECSGY8410000
      Chemical formulaC₁₆H₂₄O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityMethanol (2 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 1369
      ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
      Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Ridgway, N.D., et al. 1995. J. Biol. Chem. 270, 8023.
      Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
      Ktistakis, N.Y., et al. 1992. Nature 356, 344.
      Citation
    • Michael Tscharntke, et al. (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. The FASEB Journal in press,.
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
      		•