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548000 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt - CAS 5108-96-3 - Calbiochem

Cell permeable. Inhibits the induction of NOS activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: APDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄

Primary Target: Induction of nitric oxide synthase activity in rat alveolar macrophages
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      5108-96-3C₅H₁₂N₂S₂
      Description
      OverviewCell permeable. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells. Inhibits NF-κB activation and HIV replication in lymphocytes.
      Catalogue Number548000
      Brand Family Calbiochem®
      SynonymsAPDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄
      References
      ReferencesTsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667.
      Pan, Z., et al. 1995. J. Biol. Chem. 270, 7787.
      Bessho, R., et al. 1994. Biochem. Pharmacol. 48, 1883.
      Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun. 191, 1301.
      Schreck, R., et al. 1992. J. Exp. Med. 175, 1181.
      Product Information
      CAS number5108-96-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₅H₁₂N₂S₂
      Chemical formulaC₅H₁₂N₂S₂
      HS Code2933 59 99
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInduction of nitric oxide synthase activity in rat alveolar macrophages
      Purity≥98% by titration
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.



      From Catalog:
      Desc. Field- added "cell-permeable
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      548000 0

      Documentation

      1-Pyrrolidinecarbodithioic Acid, Ammonium Salt - CAS 5108-96-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      1-Pyrrolidinecarbodithioic Acid, Ammonium Salt - CAS 5108-96-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      548000

      Literatur

      Übersicht
      Tsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667.
      Pan, Z., et al. 1995. J. Biol. Chem. 270, 7787.
      Bessho, R., et al. 1994. Biochem. Pharmacol. 48, 1883.
      Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun. 191, 1301.
      Schreck, R., et al. 1992. J. Exp. Med. 175, 1181.

      Broschüre

      Titel
      Caspases and other Apoptosis Related Tools Brochure
      Pathways and Biomarkers of Oxidative Stress

      Literaturstellen

      Titel
    • Teresa Sanchez Alcaraz, et al. 2004. Journal of Virology 78, 6180.
      		•
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2008 RFH
      SynonymsAPDC, Ammonium Pyrrolidinedithiocarbamate, PDTC, NH₄
      DescriptionCell permeable. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells. Inhibits NF-κB activation and HIV replication in lymphocytes.
      FormWhite solid
      CAS number5108-96-3
      Chemical formulaC₅H₁₂N₂S₂
      Structure formulaStructure formula
      Purity≥98% by titration
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 3 months at -20°C.



      From Catalog:
      Desc. Field- added "cell-permeable
      Toxicity Irritant
      ReferencesTsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667.
      Pan, Z., et al. 1995. J. Biol. Chem. 270, 7787.
      Bessho, R., et al. 1994. Biochem. Pharmacol. 48, 1883.
      Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun. 191, 1301.
      Schreck, R., et al. 1992. J. Exp. Med. 175, 1181.
      Citation
    • Teresa Sanchez Alcaraz, et al. 2004. Journal of Virology 78, 6180.
      		•