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345868 [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem

An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1).

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Synonyme: 1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone

Primary Target: Activator Protein-1 (AP-1)
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      23513-14-6C₁₇H₂₆O₄
      Description
      OverviewAn antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). Also increases the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum (EC50 = 4 µM) and increases Ca2+ uptake.
      Catalogue Number345868
      Brand Family Calbiochem®
      Synonyms1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone
      References
      ReferencesBode, A.M., et al. 2001. Cancer Res. 61, 850.
      Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227.
      Park, K.K.,et al. 1998. Cancer Lett. 129, 139.
      Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.
      Product Information
      CAS number23513-14-6
      ATP CompetitiveN
      FormPale yellow oil
      Hill FormulaC₁₇H₂₆O₄
      Chemical formulaC₁₇H₂₆O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetActivator Protein-1 (AP-1)
      Primary Target IC<sub>50</sub>EC50 = 4 µM increasing the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSHE0757000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      345868 0

      Documentation

      [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      [6]-Gingerol, Zingiber officinale - CAS 23513-14-6 - Calbiochem Analysenzertifikate

      TitelChargennummer
      345868

      Literatur

      Übersicht
      Bode, A.M., et al. 2001. Cancer Res. 61, 850.
      Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227.
      Park, K.K.,et al. 1998. Cancer Lett. 129, 139.
      Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-June-2008 RFH
      Synonyms1-(4ʹ-Hydroxy-3ʹ-methoxyphenyl)-5-hydroxy-3-decanone
      DescriptionPhytochemical compound isolated from the extract of rhizome of ginger. Along with other related compounds found in ginger extracts inhibits prostaglandin and leukotriene biosynthesis through the suppression of 5-lipoxygenase and prostaglandin synthetase. Also exhibits anti-tumor and apoptosis-inducing effects. Blocks EGF-induced cell transformation by inhibiting the activation of Activator protein-1 (AP-1). Shown to inhibit the EGF-induced, sequence-specific DNA-binding of AP-1. Does not effect EGF-induced phosphorylation of ERK or p38 kinases. Also increases the Ca2+-ATPase activity of the sarcoplasmic reticulum (EC50 = 4 µM).
      FormPale yellow oil
      Intert gas (Yes/No) Packaged under inert gas
      CAS number23513-14-6
      RTECSHE0757000
      Chemical formulaC₁₇H₂₆O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.
      Toxicity Harmful
      ReferencesBode, A.M., et al. 2001. Cancer Res. 61, 850.
      Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther. 290, 227.
      Park, K.K.,et al. 1998. Cancer Lett. 129, 139.
      Kobayashi, M., et al. 1987. Biochim. Biophys. Acta 903, 96.