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126920 ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem

ALDH2 Agonist, Alda-1, CAS 349438-38-6, is a cell-permeable, selective enhancer the activity of both the wild-type ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial ALDH2.

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Synonyme: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      349438-38-6C₁₅H₁₁Cl₂NO₃
      Description
      OverviewA cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
      Catalogue Number126920
      Brand Family Calbiochem®
      SynonymsN-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
      References
      ReferencesChen, C.H., et al. 2008. Science 321, 1493.
      Product Information
      CAS number349438-38-6
      DeclarationPatent pending.
      FormOff-white solid
      Hill FormulaC₁₅H₁₁Cl₂NO₃
      Chemical formulaC₁₅H₁₁Cl₂NO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationALDH2 Agonist, Alda-1, CAS 349438-38-6, is a cell-permeable, selective enhancer the activity of both the wild-type ALDH2*1 and the East Asian E487K mutant ALDH2*2 forms of mitochondrial ALDH2.
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      126920 0

      Documentation

      ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      ALDH2 Agonist, Alda-1 - CAS 349438-38-6 - Calbiochem Analysenzertifikate

      TitelChargennummer
      126920

      Literatur

      Übersicht
      Chen, C.H., et al. 2008. Science 321, 1493.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-March-2014 JSW
      SynonymsN-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
      DescriptionA cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number349438-38-6
      Chemical formulaC₁₅H₁₁Cl₂NO₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, C.H., et al. 2008. Science 321, 1493.