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505855 Adenovirus Proteinase Inhibitor, NSC 37249 - CAS 2907-88-2 - Calbiochem

An inhibitor of adenovirus cysteine proteinase AVP that simultaneously targets AVP co-factor pVIc N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM).

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Synonyme: AVP Inhibitor, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide

Primary Target: AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket
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505855
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
2907-88-2C₄₀H₅₈N₄O₄S

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      		 Glasflasche 10 mg
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      Description
      OverviewA sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM), blocking both AVP-pVIc active complex formation (IC50 = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM) and catalytic activity (IC50 = 490 nM; [substrate] = 5 µM) without affecting trypsin or papain protease activity even at concentrations as high as 10 µM.
      Catalogue Number505855
      Brand Family Calbiochem®
      SynonymsAVP Inhibitor, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide
      References
      ReferencesMcGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.
      Product Information
      CAS number2907-88-2
      FormOff-white powder
      Hill FormulaC₄₀H₅₈N₄O₄S
      Chemical formulaC₄₀H₅₈N₄O₄S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket
      Secondary targetAVP-pVIc substrate-binding site
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5058550001 04055977263091

      Documentation

      Adenovirus Proteinase Inhibitor, NSC 37249 - CAS 2907-88-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      McGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-January-2014 JSW
      SynonymsAVP Inhibitor, 2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide
      DescriptionA sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus AVP, the cysteine proteinase critical for virion assembly and maturation, by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM), blocking not only AVP-pVIc active complex formation/AVP activation (IC50 = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM), but also AVP-pVIc active complex catalytic activity (IC50 = 490 nM; [substrate] = 5 µM). Does not affect the activity of the serine protease trypsin or the cysteine protease papain even at concentrations as high as 10 µM.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number2907-88-2
      Chemical formulaC₄₀H₅₈N₄O₄S
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Solubility5% TFA in EtOH (5 mg/ml). Not soluble in DMSO.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMcGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.