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MABC1189-25UG Anti-Bin3 Antibody, clone 3A4

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MABC1189-25UG
25 μg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC1189-25UG
      DescriptionAnti-Bin3 Antibody, clone 3A4
      Alternate Names
      • Bridging integrator 3
      Background InformationBridging integrator 3 (UniProt: Q9NQY0; also known as Bin3) is encoded by the BIN3 gene (Gene ID: 55909) in human. Bin3 is a cytoskeletal protein that is ubiquitously expressed except in brain and is involved in cytokinesis and septation where it has a role in the localization of F-actin. It contain one BAR domain (aa 9-232), which forms coiled-coil structures. The BAR domain interacts with and facilitates tubulation of curved membranes and also binds to small GTPases and other cell regulatory proteins in the cytosol and nucleus. Deletion of Bin3 in mice is shown to cause cataracts associated with actin defects. Bin 3 I shown to suppress lymphoma during aging and restricts the efficiency of lung carcinogenesis. It is also shown to restrict the proliferation and motility of oncogenically transformed cells. (Ref.: Ramalingam, A., et al. (2008). Cancer Res. 68 (6): 1683-1690).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect using this mouse monoclonal Anti-Bin3, clone 3A4 Antibody, Cat. No. MABC1189-25UG, validated for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 4 µg/mL from a representative lot detected Bin3 in 10 µg of  MCF7 and HEK293 cell lysate.
      Western Blotting Analysis: A representative lot detected Bin3 in Western Blotting applications (Ramalingam, A., et. al. (2008). Cancer Res. 68(6):1683-90).
      Biological Information
      ImmunogenGST-tagged full length recombinant human Bridging integrator 3 (Bin3).
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 3A4 detects Bridging integrator 3 (Bin3) in human and mouse cells.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • BIN3
      Purification MethodProtein G purified
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.
      Western Blotting Analysis: 4 µg/mL of this antibody detected Bin3 in 10 µg of  HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABC1189-25UG 04054839431760

      Documentation