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MABN1861 Anti-Kallikrein 8/KLK8 Antibody, clone 19-10

Anti-Kallikrein 8/KLK8 Antibody, clone 19-10 is an antibody against Kallikrein 8/KLK8 for use in Western Blotting, Immunohistochemistry (Paraffin), ELISA, Activity Assay.

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Research Category: Neuroscience Research Sub-Category: Signaling Neuroscience Gene Symbol: KLK8, NP, NRPN, PRSS19, TADG14 UniProt Number: O60259
MABN1861
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IH(P), ELISA, ACTMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1861
      DescriptionAnti-Kallikrein 8/KLK8 Antibody, clone 19-10
      Alternate Names
      • Kallikrein-8
      • hK8
      • hNP
      • Neuropsin
      • NP
      • Ovasin
      • Serine protease 19
      • Serine protease TADG-14
      • Tumor-associated differentially expressed gene 14 protein
      Background InformationKallikrein-8 (EC 3.4.21.118; UniProt O60259; also known as hK8, hNP, Neuropsin, NP, Ovasin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein) is encoded by the KLK8 (also known as NP, NRPN, PRSS19, TADG14) gene (ORF UNQ283/PRO322; Gene ID 11202) in human. Kallikrein-8 is a member of the kallikrein subfamily of serine proteases, members of which are involved in diverse physiological functions and many are used as biomarkers for cancer. Kallikrein-8 is initially produced as a preproprotein with a signal (aa 1-28) and a propeptide (aa 29-32), cleavage of which releases the mature protein (aa 33-260). Kallikrein-8 and six other kallikreins (5, 6, 7, 10, 11, 13, and 14) are co-expressed in the outermost epidermal layer stratum corneum (SC), hair follicles, sebaceous and sweat glands, with kallikrein-8 being the most abundant trypsin-like kallikrein in SC and sweat. In addition to its involvement in epidermal homeostasis and wound healing, kallikrein-8 is also found to mediate the entry of human papillomaviruses (HPVs) into host cells.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in 0.1 M sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Kallikrein 8/KLK8 Antibody, clone 19-10 is an antibody against Kallikrein 8/KLK8 for use in Western Blotting, Immunohistochemistry (Paraffin), ELISA, Activity Assay.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      • ELISA
      • Activity Assay
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Kallikrein 8/KLK8 in human cerebellum, mouse cerebellum, human kidney, and human pancreas.
      ELISA Analysis: A representative lot was employed as the capture antibody for the detection of human LPL in patients-derived ovarian tumor cytosolic extracts by sandwich ELISA (Borgono, C.A., et al. (2006). Clin. Cancer Res. 12(5):1487-1493).
      Activity Assay: A representative lot was employed to capture/isolate Kallikrein 8 (KLK8) from human sweat samples and epidermis stratum corneum (SC) extracts, as well as recombinant mature human KLK8 for activity assay (Eissa, A., et al. (2011). J. Biol. Chem. 286(1): 687–706).
      Biological Information
      ImmunogenRecombinant full-length human kallikrein 8.
      Clone19-10
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 19-10 recognizes an epitope present in mature Kallikrein 8 (KLK8), it will therefore reacts with both pro- and mature human Kallikrein 8 (KLK8) spliced isoforms 1 and 2. Reactivity toward human spliced isoform 3 has not been determined (UniProt O60259-3). Clone 19-10 does not inhibit KLK8 enzymatic activity.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KLK8
      • NP
      • NRPN
      • PRSS19
      • TADG14
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight28 kDa observed. 28.05 kDa (Prepro isoform 1), 32.97 kDa (Prepro isoform 2), 26.72 kDa (Pro-form), and 24.46 kDa (Mature) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human testis tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Kallikrein 8/KLK8 in 10 µg of human testis tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABN1861 04055977332223