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ABN174 Anti-MNX1 (HB9) Antibody

Anti-MNX1 (HB9), Cat. No. ABN174, is a rabbit polyclonal antibody that detects MNX1 and is tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-MNX1 (HB9) Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Transcription Factors Gene Symbol: MNX1, HLXB9, HB9 UniProt Number: P50219
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ABN174
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN174
      DescriptionAnti-MNX1 (HB9) Antibody
      Alternate Names
      • Motor neuron and pancreas homeobox protein 1
      • Homeobox protein HB9
      Background InformationMotor neuron and pancreas homeobox protein 1 (UniProt: P50219; also known as Homeobox protein HB9) is encoded by the MNX1 (also known as HLXB9) gene (Gene ID: 3110) in human. MNX1 is a transcription factor that is expressed in lymphoid and pancreatic tissues. Its DNA binding homeobox region is localized in amino acids 241-300. It recognizes and binds to the regulatory elements of target genes and negatively modulates transcription. It plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4. It is involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex. It is also involved in pancreas development and function and may play a role in pancreatic cell fate specification. MNX1 is reported to be abnormally overexpressed in cervical cancer and its high expression is correlated with poorer clinicopathologic characteristics. It accelerates cell cycle transition by transcriptionally downregulating p21. It is also a critical regulator for normal pancreas and loss-of-function mutations are known to cause neonatal diabetes. Mutations in MNX1 gene have been linked to Currarino syndrome, an autosomal disorder that is caused by dorsal-ventral patterning defects during embryonic development. Two isoforms of MNX1 have been described that are produced by alternative splicing. (Ref.: Zhu, B., et al. (2020). Front. Oncol. 10; 1307; Schwaller, J. (2019). Haematologica. 104(1); 1-3).
      References
      Product Information
      FormatAffinity Purified
      Control
      • PANC-1 cell lysate
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-MNX1 (HB9), Cat. No. ABN174, is a rabbit polyclonal antibody that detects MNX1 and is tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesTested Applications

      Immunohistochemistry (Paraffin) Analysis: A 1:1,000 dilution from a representative lot detected MNX1 in Human pancreas and Mouse brain tissue sections.

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 18 amino acids from the C-terminal half of Motor neuron and pancreas homeobox protein 1 (MNX1).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody detects Motor neuron and pancreas homeobox protein 1 (MNX1). It targets an epitope within 18 amino acids from the C-terminal half.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteHuman, Mouse. Predicted to react with Canine, Bovine, Monkey, Feline, Porcine based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MNX1
      • HLXB9
      • HB9
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~47 kDa observed; 40.57 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PANC-1 cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected MNX1 in PANC-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsRecommended storage: +2°C to +8°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABN174 04053252695797

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies