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ABN408 Anti-MPRIP Antibody

Anti-MPRIP Antibody detects level of MPRIP & has been published & validated for use in MPRIP.

Anti-MPRIP Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: MPRIP, KIAA0864, MRIP, RHOIP3 UniProt Number: Q6WCQ1
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ABN408
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN408
      DescriptionAnti-MPRIP Antibody
      Alternate Names
      • Myosin phosphatase Rho-interacting protein
      • M-RIP
      • Rho-interacting protein 3
      • RIP3
      • p116Rip
      Background InformationMPRIP, also known as Myosin phosphatase Rho-interacting protein, M-RIP, Rho-interacting protein 3, RIP3, or p116Rip, and encoded by the gene MPRIP/KIAA0864/MRIP/RHOIP3, is an important regulator or actin cytoskeleton interactions. In muscle and neurons MPRIP targets myosin phosphatase to the actin cytoskeleton and its interaction with phosphorylated myosin. Overexpression of MPRIP leads to disassembly of actin stress fibers in neuronal and other cells types. MPRIP though its interaction with the actin cytoskeleton modulates cell morphology, particularly in neurons and strongly structural cell types, and MPRIP appears to play a key role in the JNK signaling cascade and in cell motility in invasive cancer cells, thus MPRIP is a current target for anti-cancer therapy. MPRIP interacts with RHOA, ROCK, MYZAP, Syntenin-1 and other cell structure associated proteins. MPRIP co-localizes with F-actin in most cells, and thus it is largely cytoplasmically localized.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-MPRIP Antibody detects level of MPRIP & has been published & validated for use in MPRIP.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected MPRIP in human stomach and human cerebellum tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human MPRIP.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteHuman, Rat. Predicted to react with Chimpanzee, Canine, Feline, Ferret, Gorilla, Giant Panda based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MPRIP
      • KIAA0864
      • MRIP
      • RHOIP3
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~135 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SH-SY5Y cell lysate.

      Western Blotting Analysis: 3.0 µg/mL of this antibody detected MPRIP in 10 µg of SH-SY5Y cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABN408 04053252944628