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ABE2586 Anti-NR2F2 (ARP-1) isoform B

Anti-NR2F2 isoform B, Cat. No. ABE2586, is a highly specific rabbit polyclonal antibody that targets Nuclear receptor subfamily 2 group F member 2. and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-NR2F2 (ARP-1) isoform B: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Epigenetics & Nuclear Function Gene Symbol: NR2F2, ARP1, TFCOUP2 UniProt Number: P24468-2
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ABE2586
100 μg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIH(P), WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE2586
      DescriptionAnti-NR2F2 (ARP-1) isoform B
      Alternate Names
      • COUP transcription factor 2
      • COUP-TF2
      • Apolipoprotein A-I regulatory protein 1
      • ARP-1
      • COUP transcription factor II
      • COUP-TF II
      • Nuclear receptor subfamily 2 group F member 2
      Background InformationCOUP transcription factor 2 (UniProt: P24468-2; also known as COUP-TF2, COUP-TF II, Apolipoprotein A-I regulatory protein 1, ARP-1, COUP transcription factor II, COUP-TF II, Nuclear receptor subfamily 2 group F member 2) is encoded by the NR2F2 (also known as ARP1, TFCOUP2) gene (Gene ID: 7026) in human. Coup-TF II is a ligand-activated transcription factor that is activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid. Its DNA binding region is localized in amino acids 76-151. COUP-TF II contains two NR C4-type zinc finger domains (aa 79-99 and 115-139). It is widely distributed in human tissues with detectable expression in all tissues examined. Its tissue and cell-specific expression can be modulated both transcriptionally and post-translationally. Through binding to 5 -AGGTCA-3 direct repeats (DRs) with variable spacing, it can modulate the expression of target genes, such as RA receptor beta 2, PEPCK, NGFI-A, and cholesterol 7 -hydroxylase. COUP-TF II action can also be enhanced by interaction with certain coactivators, such as with members of the steroid receptor coactivator family members SRC-1, SRC-2, and SRC-3. Mutations in NR2F2 gene have been linked to multiple types of congenital heart defects characterized transposition of the great arteries, aortic stenosis, and ventricular septal defect. (Ref.: Litchfield, LM and Klinge, CM (2012). J. Mol. Endocrinol. 49 (3); R135-R148).
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-NR2F2 isoform B, Cat. No. ABE2586, is a highly specific rabbit polyclonal antibody that targets Nuclear receptor subfamily 2 group F member 2. and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesWestern Blotting Analysis: 2 µg/mL from a representative lot detected NR2F2 isoform B in in 10 µg of L6 cell lysate.

      Western Blotting Analysis: A representative lot detected NR2F2 isoform B in MEWO cells overexpressing NR2F2 isoform B.(Courtesy of Claudia Lovell at Hernando Lab, NYU Langone Medical Center).

      Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected NR2F2 isoform B in human kidney, human pancreas, and human cerebellum tissues.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the first 14 amino acids from the N-terminus region of human COUP transcription factor 2 (ARP1), isoform B.
      EpitopeN-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis rabbit polyclonal antibody detects COUP-TF II. It targets an epitope within 14 amino acids from the N-terminus region of isoform B.
      IsotypeIgG
      Species Reactivity
      • Rat
      Species Reactivity NoteRat. Predicted to react with Human, Sheep, Mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NR2F2
      • ARP1
      • TFCOUP2
      Modifications
      • Variant/Isoform
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~37kDa observed; 31.48 kDa calculated for isoform B. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC12 cell lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected NR2F2 isoform B in in 10 µg of PC12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABE2586 04054839416545