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MABN394 Anti-PSMD9 Antibody, clone 16C5.1

Anti-PSMD9 Antibody, clone 16C5.1 is an antibody against PSMD9 for use in Western Blotting, Immunohistochemistry (Paraffin).

Anti-PSMD9 Antibody, clone 16C5.1 : SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Ubiquitin & Ubiquitin Metabolism Gene Symbol: PSMD9 UniProt Number: O00233
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MABN394
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN394
      DescriptionAnti-PSMD9 Antibody, clone 16C5.1
      Alternate Names
      • 26S proteasome non-ATPase regulatory subunit 9
      • 26S proteasome regulatory subunit p27
      • Homolog of rat Bridge 1
      • Proteasome macropain non-ATPase subunit 9
      Background Information26S proteasome non-ATPase regulatory subunit 9 (UniProt O00233; also known as 26S proteasome regulatory subunit p27, Homolog of rat Bridge 1, Proteasome macropain non-ATPase subunit 9) is encoded by the PSMD9 gene (Gene ID 5715) in human. PSMD9 is a proteasomal assembly chaperone that forms a stable subcomplex with two AAA-ATPases, PSMC3 and PSMC6, in assisting the assembly of the 20S and 19S particles to form the holo complex. PSMD9 contains a PDZ-like domain (a.a. 108-195) that is reported to interact with a short 4- to 7-amino acid linear sequence motifs (SLIMs) at the C-terminal end of its client proteins, including the RNA-binding protein hnRNPA1, the ribosomal protein S14, the growth hormone CSH1, the transcription factor E12, and the IL6 receptor. PSMD9 and hnRNPA1 interaction is found to play a role in IκBα proteasomal degradation, where hnRNPA1 functions as shuttle receptor that recruits IκBα to the proteasome for degradation.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-PSMD9 Antibody, clone 16C5.1 is an antibody against PSMD9 for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern Blotting Analysis: 0.5 µg/mL from a representative lot detected PSMD9 in 10 µg of HepG2 cell lysate.
      Immunohistochemistry Analysis: An 1:50 dilution from a representative lot detected PSMD9 in normal human kidney and prostate tissues, as well as human prostate cancer tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant human PSMD9 internal fragment.
      EpitopeInternal.
      Clone16C5.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with spliced isoforms p27-L and p27-S, but not spliced isoform 3.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PSMD9
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~26 kDa observed. 24.68 kDa (isoforms p27-L) and 22.76 kDa (isoforms p27-S) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SHSY-5Y cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected PSMD9 in 10 µg of SHSY-5Y cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MABN394 04055977329520