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266788 Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem

The Diacylglycerol Kinase Inhibitor II, also referenced under CAS 120166-69-0, controls the biological activity of Diacylglycerol KInase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonyme: R59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II

Primary Target: Diacylglycerol Kinase
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      120166-69-0C₂₈H₂₅F₂N₃OS
      Description
      OverviewInhibits diacylglycerol kinase in isolated platelet membranes (IC50 = 300 nM) and in intact platelets (IC50 = 120 nM) by binding to the catalytic domain. A more potent analog of diacylglycerol kinase inhibitor I (Cat. No. 266785).
      Catalogue Number266788
      Brand Family Calbiochem®
      SynonymsR59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II
      References
      ReferencesJiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
      Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
      Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
      de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.
      Product Information
      CAS number120166-69-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₈H₂₅F₂N₃OS
      Chemical formulaC₂₈H₂₅F₂N₃OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDiacylglycerol Kinase
      Primary Target IC<sub>50</sub>300 nM and 120 nM against diacylglycerol kinase in isolated platelet membranes and in intact platelets, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      266788 0

      Documentation

      Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem Analysenzertifikate

      TitelChargennummer
      266788

      Literatur

      Übersicht
      Jiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
      Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
      Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
      de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.

      Literaturstellen

      Titel
    • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
      		•
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-March-2009 RFH
      SynonymsR59949, 3-{2-[4-[bis-(4-Fluorophenyl)methylene]-1-piperidinyl]ethyl}-2,3-dihydro-2-thioxo-4(1H)quinazolinone, DGK Inhibitor II
      DescriptionInhibitor useful for elucidating roles of protein kinase C. Inhibits diacylglycerol (DAG) kinase in isolated platelet membranes (IC50 = 300 nM) and in intact platelets (IC50 = 120 nM). A more potent analog of DAG kinase inhibitor I.
      FormWhite solid
      CAS number120166-69-0
      Chemical formulaC₂₈H₂₅F₂N₃OS
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (12.5 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, flush with an inert gas and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesJiang, Y., et al. 2000. Biochem. Pharmacol. 59, 763.
      Jones, D.R., et al. 1999. J. Biol. Chem. 274, 16846.
      Rodriguez-Linares, B., et al. 1991. Biochem. Pharmacol. 41, 835.
      de Chaffoy de Courcelles, D., et al. 1989. J. Biol. Chem. 264, 3274.
      Citation
    • Fernando C. Gómez-Merino, et al. (2005) Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases, displays unique biochemical features and saturates at low substrate concentration-the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro, and alters plan. Journal of Biological Chemistry 280, 34888-34899.
    • Rick B. Vega, et al. (2004) Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5. Molecular and Cellular Biology 24, 8374-8385.
      		•