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05-23-3800 Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.

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Synonyme: ET-1, CSCSSLMDKECVYFCHLDIIW

Primary Target: Potent vasoconstrictive action
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      117399-94-7C₁₀₉H₁₅₉N₂₅O₃₂S₅
      Description
      OverviewA 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
      Catalogue Number05-23-3800
      Brand Family Calbiochem®
      SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
      References
      ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
      Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
      Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
      Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
      Yanagisawa, M., et al. 1988. Nature 332, 411.
      Product Information
      CAS number117399-94-7
      ATP CompetitiveN
      FormWhite to off-white solid
      FormulationSupplied as an acetate salt.
      Hill FormulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
      Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPotent vasoconstrictive action
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      05-23-3800 0

      Documentation

      Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem Analysenzertifikate

      TitelChargennummer
      05-23-3800

      Literatur

      Übersicht
      Cesari, M., et al. 1996. Am. Heart J. 132, 1236.
      Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
      Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
      Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
      Yanagisawa, M., et al. 1988. Nature 332, 411.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-May-2008 JSW
      SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
      DescriptionA 21 amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
      FormWhite to off-white solid
      FormulationSupplied as an acetate salt.
      CAS number117399-94-7
      Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
      Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
      Purity≥96% by HPLC
      Solubility5% Acetic acid (0.5 mg/ml). Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with distilled water to achieve 5% acetic acid and 0.5 mg/ml peptide.
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
      Toxicity Standard Handling
      ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
      Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
      Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
      Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
      Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
      Yanagisawa, M., et al. 1988. Nature 332, 411.