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19-164 HA1077

HA1077: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Uni Prot Number: O75116, Q16513, O75582, P51812, P17612, P23443, Q15746
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19-164
5 mg  
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      Übersicht

      Replacement Information

      Key Spec Table

      Uni Prot Number
      O75116 Q16513 O75582 P51812 P17612 P23443 Q15746
      Description
      Catalogue Number19-164
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionHA1077
      References
      Product Information
      PresentationC14H17N3O2S2HCl
      Quality LevelMQ100
      Applications
      Key Applications
      • Kinase Assay
      Application NotesInhibits ROKa/ROCK II, PRK2, MSK1, Rsk2, PKA, p70 S6 Kinase, CaM Kinase and MLCK.
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
      Gene Symbol
      • ROCK2
      • KIAA0619
      Protein TargetRho kinase 2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16513 # Exhibits a preference for highly basic protein substrates (By similarity).
      SIZE: 984 amino acids; 112035 Da
      SUBCELLULAR LOCATION: Cytoplasm (By similarity).
      DOMAIN:SwissProt: Q16513 The C1 domain does not bind the diacylglycerol (DAG).
      PTM: Autophosphorylated. & Activated by limited proteolysis with trypsin (By similarity).
      SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 C2 domain. & Contains 1 protein kinase domain. & Contains 3 REM (Hr1) repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C
      Packaging Information
      Material Size5 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      19-164 04053252728730

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      Kategorien

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors