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524644 L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem

A component of membrane-bound receptors in association with phospholipase C (PLC).

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: PIP₂

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      383907-42-4C₄₇H₈₂O₁₉P₃ · 3NH₄
      Description
      OverviewA component of membrane-bound receptors in association with phospholipase C (PLC). Potently stimulates brain phospholipase D (PLD) activity in vitro. Has been shown to activate protein kinase C (PKC) in the presence of phosphatidylserine and Ca2+. Antagonist of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.
      Catalogue Number524644
      Brand Family Calbiochem®
      SynonymsPIP₂
      References
      ReferencesBaukrowitz, T., et al. 1998. Science 282, 1141.
      Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
      Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
      Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
      Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
      Williamson, J.R. 1986. Hypertension 8, 140.
      Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.
      Product Information
      CAS number383907-42-4
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₄₇H₈₂O₁₉P₃ · 3NH₄
      Chemical formulaC₄₇H₈₂O₁₉P₃ · 3NH₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBrain phospholipase D (PLD)
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      524644 0

      Documentation

      L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      L-α-Phosphatidyl-D-myo-inositol-4,5-bisphosphate, Triammonium Salt, Porcine Brain - CAS 383907-42-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      524644

      Literatur

      Übersicht
      Baukrowitz, T., et al. 1998. Science 282, 1141.
      Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
      Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
      Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
      Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
      Williamson, J.R. 1986. Hypertension 8, 140.
      Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-August-2015 JSW
      SynonymsPIP₂
      DescriptionA component of membrane-bound receptors in association with phospholipase C. Hydrolysis of PIP2 yields IP3 and diacylglycerol, causing the release of intracellular Ca2+ and activation of protein kinase C. Potently stimulates phospholipase D activity in vitro in brain tissue. A substrate for PI 3-kinase. Antagonist of ATP inhibtion of ATP-sensitive potassium (KATP) channels when applied to inside-out membrane patches.

      Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number383907-42-4
      Chemical formulaC₄₇H₈₂O₁₉P₃ · 3NH₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityCHCl₃ (50 mg/ml) or H₂O (10 mg/ml)
      Storage Protect from light
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in H₂O, store in the refrigerator (4°C). Do not freeze aqueous solutions. Following reconstitution in chloroform, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 days at 4°C. Chloroform stock solutions are stable for up to 1 month at -20°C.
      Toxicity Irritant
      ReferencesBaukrowitz, T., et al. 1998. Science 282, 1141.
      Shyng, S.-L., and Nichols, C.G. 1998. Science 282, 1138.
      Mazzotti, G., et al. 1995. J. Histochem. Cytochem. 43, 181.
      Liscovitch, M., et al. 1994. J. Biol. Chem. 269, 21403.
      Chauhan, A., et al. 1991. Biochem. Biophys. Res. Commun. 175, 852.
      Williamson, J.R. 1986. Hypertension 8, 140.
      Berridge, M.J., and Irvine, R.F. 1984. Nature 312, 315.