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480401 NFAT Inhibitor, Cell-Permeable - Calbiochem

The NFAT Inhibitor, Cell-Permeable controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

NFAT Inhibitor, Cell-Permeable - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 11R-VIVIT, Nuclear Factor of Activated T cells Inhibitor, RRRRRRRRRRR-GGG-MAGPHPVIVITGPHEE

Primary Target: NFAT
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₄₇H₂₅₉N₆₇O₃₆S
      Description
      OverviewA cell-permeable version of NFAT Inhibitor (Cat. No. 480402) that is modified at the N-terminal with an eleven arginine transduction domain and a three glycine linker sequence. Prevents the activation and proliferation of T cells both in vitro ( ~ 43% at 1 µM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice). Shown to be effective in providing immunosuppression in a murine islet xenograft model. Unlike Cyclosporin A (Cat. No. 239835) and FK506, 11R-VIVIT does not cause side effects outside the immune system as a result of calcineurin (Cat. No. 539568) inhibition and therefore serves as a less toxic alternative for in vivo applications. The functional half-life of 11R-VIVIT has been estimated to be ~30 h in Jurkat cells.
      Catalogue Number480401
      Brand Family Calbiochem®
      Synonyms11R-VIVIT, Nuclear Factor of Activated T cells Inhibitor, RRRRRRRRRRR-GGG-MAGPHPVIVITGPHEE
      References
      ReferencesNoguchi, H., et al. 2004. Nat. Med. 10, 305.
      Product Information
      ATP CompetitiveN
      FormLyophilized white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₄₇H₂₅₉N₆₇O₃₆S
      Chemical formulaC₁₄₇H₂₅₉N₆₇O₃₆S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNFAT
      Primary Target IC<sub>50</sub>Use at 1 µM for preventing the activation and proliferation of T cells
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      480401 0

      Documentation

      NFAT Inhibitor, Cell-Permeable - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      NFAT Inhibitor, Cell-Permeable - Calbiochem Analysenzertifikate

      TitelChargennummer
      480401

      Literatur

      Übersicht
      Noguchi, H., et al. 2004. Nat. Med. 10, 305.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      Synonyms11R-VIVIT, Nuclear Factor of Activated T cells Inhibitor, RRRRRRRRRRR-GGG-MAGPHPVIVITGPHEE
      DescriptionA cell-permeable version of NFAT Inhibitor (Cat. No. 480402) that is modified at the C-terminus with an 11-arginine transduction domain and a 3-glycine linker sequence. Prevents the activation and proliferation of T cells both in vitro (~43% at 1 µM using mixed lymphocyte cultures) and in vivo (10 mg/kg using C3H/HeN mice). Show to be effective in providing immunosuppression in a murine islet xenograft model. Unlike Cyclosporin A (Cat. No. 239835) and FK-506, 11R-VIVIT does not cause side effects outside the immune system as a result of calcineurin (Cat. No. 539568) inhibition, therefore serves as a less toxic alternative for animal studies. The functional half-life of 11R-VIVIT has been estimated to be ~30 h in Jurkat cells.
      FormLyophilized white solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄₇H₂₅₉N₆₇O₃₆S
      Peptide SequenceH-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesNoguchi, H., et al. 2004. Nat. Med. 10, 305.