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14-683M PAK3 Protein, active, 250 µg

Active, C-terminal 6His-tagged, recombinant, human full length, PAK3. For use in Kinase Assays.

PAK3 Protein, active, 250 µg: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
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14-683M
250 µg  Also available in 10 μg size (cat#14-683) and in bulk (cat#14-683-K).
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      Übersicht

      Replacement Information
      Description
      Catalogue Number14-683M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPAK3 Protein, active, 250 µg
      OverviewC-terminal 6His-tagged, recombinant, human full length, PAK3.

      mitosis
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, C-terminal 6His-tagged, recombinant, human full length, PAK3. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourcePAK3 expressed by baculovirus in Sf21 cells.
      Entrez Gene Number
      Entrez Gene SummaryPAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.
      Gene Symbol
      • PAK3
      • oligophrenin-3
      • CDKN1A
      • OPHN3
      • PAK3beta
      • PAK-3
      • Beta-PAK
      • OTTHUMP00000062894
      • Oligophrenin-3
      • hPAK3
      • MRX47
      • MRX30
      • bPAK
      Protein TargetPAK3
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O75914 # Key regulator of synapse formation and plasticity in the hippocampus (By similarity).
      COFACTOR: Magnesium (By similarity).
      SIZE: 559 amino acids; 62310 Da
      SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.
      TISSUE SPECIFICITY: Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
      PTM: Autophosphorylated when activated by CDC42/p21.
      DISEASE: SwissProt: O75914 # Defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X- linked mental retardation type 47 (MRX47). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs.
      SIMILARITY: SwissProt: O75914 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain.
      Molecular Weight63.2kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of PAKtide (RRRLSFAEPG).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-683) and in bulk (cat#14-683-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      14-683M 04053252925160

      Verwandte Produkte & Anwendungen

      Alternative Packsize

      Bestellnummer Beschreibung  
      14-683 PAK3 Protein, active, 10 µg Preis & Verfügbarkeit

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      Kategorien

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases