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529625 Polyphosphoinositide-Binding Peptide, PBP10 - CAS 794466-45-8 - Calbiochem

A Rhodamine-B-labeled decapeptide derived from the (PIP₂)-binding region in segment-2 of gelsolin.

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Synonyme: RhoB-GS160-169, Rhodamine B-QRLFQVKGRR-OH

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      794466-45-8C₈₄H₁₂₇N₂₄O₁₅
      Description
      OverviewA Rhodamine-B-labeled decapeptide derived from the (PIP2)-binding region in segment-2 of gelsolin. Acts as a cell-permeable, reversible, and non-toxic agent that transiently disrupts actin filaments, which are essential for cell morphology and cell motility (~1-10 µM). Specifically binds to polyphosphoinositide (PPI) with high affinity and activates platelet without significantly affecting intracellular Ca2+ influx. Undergoes a reduction in fluorescence intensity upon binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid; the fluorescence is not affected in the presence of phosphatidylserine and phosphatidylcholine. Useful fluorescent probe for the cellular localization and stabilization of PPIs.
      Catalogue Number529625
      Brand Family Calbiochem®
      SynonymsRhoB-GS160-169, Rhodamine B-QRLFQVKGRR-OH
      References
      ReferencesBucki, R., et al. 2001. Biochemistry 40, 15752
      Cunningham, C.C., et al. 2001. J. Biol. Chem. 276, 43390.
      Product Information
      CAS number794466-45-8
      ATP CompetitiveN
      FormPinkish red lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₈₄H₁₂₇N₂₄O₁₅
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSpecifically binds to polyphosphoinositide (PPI)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Emission max.
      Excitation max.
      Peptide SequenceRho-B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      529625 0

      Documentation

      Polyphosphoinositide-Binding Peptide, PBP10 - CAS 794466-45-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Polyphosphoinositide-Binding Peptide, PBP10 - CAS 794466-45-8 - Calbiochem Analysenzertifikate

      TitelChargennummer
      529625

      Literatur

      Übersicht
      Bucki, R., et al. 2001. Biochemistry 40, 15752
      Cunningham, C.C., et al. 2001. J. Biol. Chem. 276, 43390.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-August-2008 RFH
      SynonymsRhoB-GS160-169, Rhodamine B-QRLFQVKGRR-OH
      DescriptionA Rhodamine-B-labeled decapeptide derived from the (PIP2)-binding region in segment-2 of gelsolin. Acts as a cell-permeable, reversible, and non-toxic agent that transiently disrupts actin filaments, which are essential for cell morphology and cell motility (~1-10 µM). Specifically binds to polyphosphoinositide (PPI) with high affinity and activates platelets without significantly affecting intracellular Ca2+ influx. Undergoes a reduction in fluorescence intensity upon binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid; the fluorescence is not affected in the presence of phosphatidylserine and phosphatidylcholine. Useful fluorescent probe for the cellular localization and stabilization of PPIs. Excitation max.: ~565 nm; emission max.: ~590 nm.
      FormPinkish red lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number794466-45-8
      Peptide SequenceRho-B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH
      Purity≥95% by HPLC
      SolubilityDMSO (2 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBucki, R., et al. 2001. Biochemistry 40, 15752
      Cunningham, C.C., et al. 2001. J. Biol. Chem. 276, 43390.