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553031 RAGE Antagonist Peptide, RAP - Calbiochem

The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.

RAGE Antagonist Peptide, RAP - Calbiochem: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: ELKVLMEKEL

Primary Target: RAGE
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      Übersicht

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₅₇H₁₀₁N₁₃O₁₇S
      Description
      OverviewAn S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
      Catalogue Number553031
      Brand Family Calbiochem®
      SynonymsELKVLMEKEL
      References
      ReferencesArumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.
      Product Information
      FormWhite powder
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₅₇H₁₀₁N₁₃O₁₇S
      ReversibleY
      Quality LevelMQ200
      Applications
      Biological Information
      Primary TargetRAGE
      Primary Target IC<sub>50</sub>2 µ
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceAc-ELKVLMEKEL-NH2
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      553031 0

      Documentation

      RAGE Antagonist Peptide, RAP - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      RAGE Antagonist Peptide, RAP - Calbiochem Analysenzertifikate

      TitelChargennummer
      553031

      Literatur

      Übersicht
      Arumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-October-2012 JSW
      SynonymsELKVLMEKEL
      DescriptionAn S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
      FormWhite powder
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Peptide SequenceAc-ELKVLMEKEL-NH2
      Purity≥95% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesArumugam, T., et al. 2012. Clin Cancer Res. 18, 4356.