Millipore Sigma Vibrant Logo

23-059 TRAF6, active

TRAF6, active: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Key Applications: Enzyme Assays
View Products on Sigmaaldrich.com
23-059
10 µg  
Preis wird abgerufen...
Preis nicht abrufbar
Die Mindestmenge muss ein Vielfaches sein von
Maximum Quantity is
Bei Bestätigung Weitere Informationen
Sie haben () gespart
 
—
Bitte erfragen
—
Eingeschränkte Verfügbarkeit Eingeschränkte Verfügbarkeit
Lieferbar 
Produkt wurde eingestellt
Begrenzter Lagerbestand
Bestätigung der Verfügbarkeit erforderlich
    Restmenge: Angebot folgt
      Restmenge: Angebot folgt
      Bitte erfragen
      Kontakt zum Kundenservice
      Contact Customer Service

       

      Kontakt zum Kundenservice

      Übersicht

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman E3
      Description
      Catalogue Number23-059
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionTRAF6, active
      Alternate Names
      • TNF receptor-associated factor 6
      • Interleukin-1 signal transducer
      • RING finger protein 85
      Background InformationTRAF6 is a ubiquitin ligase essential for the activation of NF-κB and MAP kinases in multiple signalling pathways including those emanating from the tumour-necrosis-factor receptor (TNFR) and interleukin-1/Toll-like receptors (IL-1R/TLR). TRAF6 also transduces signals from receptors such as CD40 and RANK and may be essential for the formation of functional osteoclasts. Studies indicate that amplification of the TRAF6 locus is a somatic and frequent event in several human cancer types and is a commonly amplified oncogene bridging RAS and NF-κB in lung cancer. Inhibition of TRAF6 in lung cancer cells has been shown to suppress NF-κB activation, anchorage-independent growth and tumour formation.
      References
      Product Information
      Quality LevelMQ100
      Applications
      Key Applications
      • Enzyme Assays
      Biological Information
      Cascade ComponentE3
      Entrez Gene Number
      Purification MethodPurified using glutathione sepharose.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      23-059 04053252959530

      Verwandte Produkte & Anwendungen

      Alternative Packsize

      Bestellnummer Beschreibung  
      23-059M TRAF6, active Preis & Verfügbarkeit

      Produktfamilien

      Ubiquitin Proteasome System: Enzymes and Substrates

      Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
      Weitere Informationen >>

      Kategorien

      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E3 Ligases
      Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases