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509892 Tetrabenazine, TBZ - CAS 58-46-8 - Calbiochem

A monoamine-depleting agent that blocks vesicular monoamine transporter 2 activity. Promotes late-stage differentiation of Pdx1 + pancreatic progenitor cells into Ngn3 + endocrine precursors.

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Synonyme: VMAT2 Inhibitor, Xenazine

Primary Target: VMAT2
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      58-46-8C₁₉H₂₇NO₃
      Description
      OverviewA cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC50 = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number509892
      Brand Family Calbiochem®
      SynonymsVMAT2 Inhibitor, Xenazine
      References
      ReferencesSakano, D., et al. 2014. Nat. Chem. Bio. 10,141.
      Jankovic, J., et al. 1997. Neurobiology 48,1358.
      Gertrude, P.Q., et al. 1959. J. Pharm. Exp. Ther. 127, 103.
      Product Information
      CAS number58-46-8
      FormOff-white powder
      Hill FormulaC₁₉H₂₇NO₃
      Chemical formulaC₁₉H₂₇NO₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVMAT2
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36-45

      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      509892 0

      Documentation

      Tetrabenazine, TBZ - CAS 58-46-8 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Sakano, D., et al. 2014. Nat. Chem. Bio. 10,141.
      Jankovic, J., et al. 1997. Neurobiology 48,1358.
      Gertrude, P.Q., et al. 1959. J. Pharm. Exp. Ther. 127, 103.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-May-2014 JSW
      SynonymsVMAT2 Inhibitor, Xenazine
      DescriptionA cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC50 = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number58-46-8
      Chemical formulaC₁₉H₂₇NO₃
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesSakano, D., et al. 2014. Nat. Chem. Bio. 10,141.
      Jankovic, J., et al. 1997. Neurobiology 48,1358.
      Gertrude, P.Q., et al. 1959. J. Pharm. Exp. Ther. 127, 103.