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05-23-2101 Vasoactive Intestinal Peptide, Human, Porcine, and Rat - CAS 40077-57-4 - Calbiochem

Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system.

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Synonyme: VIP

Primary Target: Mitogenic factor for embryonic neurons
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05-23-2101
  
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      40077-57-4C₁₄₇H₂₃₈N₄₄O₄₂S
      Description
      OverviewActs as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Inhibits the growth of human small-cell lung carcinoma (SCLC) both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC. Nitric oxide stimulates the release of this peptide.
      Catalogue Number05-23-2101
      Brand Family Calbiochem®
      SynonymsVIP
      References
      ReferencesMaruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
      Bakker, R., et al. 1993. Am. J. Physiol. 264, R362.
      Grider, J.R. 1993. Am. J. Physiol. 264, G334.
      Product Information
      CAS number40077-57-4
      ATP CompetitiveN
      FormWhite to off-white lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₄₇H₂₃₈N₄₄O₄₂S
      Chemical formulaC₁₄₇H₂₃₈N₄₄O₄₂S
      Hygroscopic Hygroscopic
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMitogenic factor for embryonic neurons
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide ContentY
      Peptide SequenceH-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      05-23-2101 0

      Documentation

      Vasoactive Intestinal Peptide, Human, Porcine, and Rat - CAS 40077-57-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Vasoactive Intestinal Peptide, Human, Porcine, and Rat - CAS 40077-57-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      05-23-2101

      Literatur

      Übersicht
      Maruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
      Bakker, R., et al. 1993. Am. J. Physiol. 264, R362.
      Grider, J.R. 1993. Am. J. Physiol. 264, G334.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-September-2008 RFH
      SynonymsVIP
      DescriptionActs as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Nitric oxide stimulates the release of this peptide. Inhibits human small-cell lung carcinoma (SCLC) in nude mice both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC.
      FormWhite to off-white lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      CAS number40077-57-4
      Chemical formulaC₁₄₇H₂₃₈N₄₄O₄₂S
      Peptide SequenceH-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
      Purity≥95% by HPLC
      Solubility5% Acetic acid (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesMaruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
      Bakker, R., et al. 1993. Am. J. Physiol. 264, R362.
      Grider, J.R. 1993. Am. J. Physiol. 264, G334.