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444898 Mastoparan - CAS 72093-21-1 - Calbiochem

A cell-permeable synthetic peptide with sequence identical to Vespula lewisii.

Mastoparan - CAS 72093-21-1 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: INLKALAALAKKIL

Primary Target: Na+,K+-ATPase activity
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444898
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
72093-21-1C₇₀H₁₃₁N₁₉O₁₅

Precios y disponibilidad

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      Description
      OverviewA cell-permeable synthetic peptide with sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Potent facilitator of the mitochondrial permeability transition pore that is reported to induce apoptosis in cultured cerebellar granule neurons by causing a dramatic increase in intracellular Ca2+. Acts as a calmodulin antagonist and activates phospholipase A2. Causes a transient Ca2+ release from the sarcoplasmic reticulum. Also reported to inhibit Na+,K+-ATPase activity (IC50 = 7.5 µM).
      Catalogue Number444898
      Brand Family Calbiochem®
      SynonymsINLKALAALAKKIL
      References
      ReferencesHirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
      Liz, S.Z., et al. 1997. Brain Res. 771, 184.
      Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
      Langel, U., et al. 1996. Regul. Peptides 62, 47.
      Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
      Igarashi, M., et al. 1993. Science 259, 77.
      Komatsu, M., et al. 1992. Endocrinology 130, 221.
      Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
      Gil, J., et al. 1991. J. Cell Biol. 113, 943.
      Product Information
      CAS number72093-21-1
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₇₀H₁₃₁N₁₉O₁₅
      Chemical formulaC₇₀H₁₃₁N₁₉O₁₅
      ReversibleN
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNa+,K+-ATPase activity
      Primary Target IC<sub>50</sub>7.5 µM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide ContentY
      Peptide SequenceH-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      444898-1MG 04055977186192

      Documentation

      Mastoparan - CAS 72093-21-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Mastoparan - CAS 72093-21-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      444898

      Referencias bibliográficas

      Visión general referencias
      Hirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
      Liz, S.Z., et al. 1997. Brain Res. 771, 184.
      Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
      Langel, U., et al. 1996. Regul. Peptides 62, 47.
      Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
      Igarashi, M., et al. 1993. Science 259, 77.
      Komatsu, M., et al. 1992. Endocrinology 130, 221.
      Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
      Gil, J., et al. 1991. J. Cell Biol. 113, 943.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-October-2015 JSW
      SynonymsINLKALAALAKKIL
      DescriptionA cell-permeable synthetic peptide with a sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Potent factor in mitochondrial permeability transition pore. Inhibits calmodulin and activates phospholipase A2. Causes a transient Ca2+ release from the sarcoplasmic reticulum.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      CAS number72093-21-1
      Chemical formulaC₇₀H₁₃₁N₁₉O₁₅
      Peptide SequenceH-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂
      Purity≥97% by HPLC
      SolubilityH₂O (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
      Liz, S.Z., et al. 1997. Brain Res. 771, 184.
      Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
      Langel, U., et al. 1996. Regul. Peptides 62, 47.
      Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
      Igarashi, M., et al. 1993. Science 259, 77.
      Komatsu, M., et al. 1992. Endocrinology 130, 221.
      Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
      Gil, J., et al. 1991. J. Cell Biol. 113, 943.