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  • Genomic instability | Life Science Research | Merck

    Learn about the environmental factors that can hinder DNA repair. There are many evidence linking genomic and epigenomic changes to disorders involving accelerated aging. Evidence points to general physiological stress and disrupted circadian. It is also possible that decreased DNA repair is also a symptom, not a cause, of aging. To investigate this possibility, researchers will need to examine changes in transcriptional regulators of repair genes, such as ncRNAs, hormones, and other chromatin modulators.
  • Neuronal Adhesion | Life Science Research | Merck

    Extracellular matrix (ECM) proteins regulate cell adhesion, differentiation, proliferation, migration, invasion, and survival. The nature of neural architecture requires an intricate relationship with the ECM.
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