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Libraries/Panels - Competitive Comparisons

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Signaling Pathway Panel & Library Applications & Characteristics

ProductsEMD
Signaling
Pathway Panels		EMD
Libraries		Supplier S
Libraries		Supplier B
Libraries
Product Characteristics
Format IndividualΔ
Vials		 96- or 384-well 96 well 96 well
Inhibitors per plate or kit 12-16 80 or > 160 80 80
Volume Lyophilized
(100 µg-5 mg)		 50 or 25 µl/well 25 µl/well 100 or 500 µl/well
Concentration User determined 10 mM 10 mM 10 mM
Example of Suitable Applications
Cost-effective pathway analysis +++ ++ ++ ++
Cell-based assays +++ +++ + +
Method development & validation ++ +++ +++ ++
Target identification in drug discovery ++ +++ +++ +
Screening for cell phenotype ++ +++ + +
Screening of new kinases + +++ + +
Inhibitor Characteristics
Cell-permeable* +++ +++ Data not provided Data not provided
Potent and Selective* +++ +++ Data not provided Data not provided
ATP-competitive* +++ +++ Data not provided Data not provided
Reversible* +++ +++ Data not provided Data not provided
HPLC purity >95%* +++ +++ +++ Data not provided
Structurally diverse ++ +++ ++ +
Pharmacologically active +++ +++ +++ Data not provided
Stable in DMSO and supplied with lot-specific HPLC data +++ +++ Data not provided Data not provided
Kit Contents and Documentation
Lot specific data +++ +++ Data not provided Data not provided
Published IC50/Ki values +++ +++ + +
Literature citations +++ +++ +++ +
Inhibitor description +++ +++ + +
Molecular weight +++ +++ +++ +++
Molecular structure +++ +++ +++ +++
CAS numbers (where available) +++ +++ +++ ++
Strucutre Data Files (SDF) +++ +++ +++ +++
Reconstitution information +++ N/A N/A N/A
Pathway description +++ N/A N/A N/A
PubChem compound ID (where available) +++ +++ ++ Data not provided
Assay layout sheet N/A +++ +++ +++
* Pertains to the majority of inhibitors
Δ Each panel also include 15 ml of anhydrous DMSO