901572
Bromo-PEG2-acid
≥95%
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About This Item
Empirical Formula (Hill Notation):
C7H13BrO4
CAS Number:
Molecular Weight:
241.08
UNSPSC Code:
12352101
NACRES:
NA.22
MDL number:
Assay:
≥95%
Form:
liquid
assay
≥95%
form
liquid
reaction suitability
reagent type: linker
functional group
bromo, carboxylic acid
storage temp.
−20°C
SMILES string
BrCCOCCOCCC(O)=O
InChI key
CCEBKJLCKKPYHB-UHFFFAOYSA-N
Application
Bromo-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
This is a crosslinker with a bromo group on one end and a carboxyl group on the other end. The compound contains two PEG units to help improve solubility.
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
10 - Combustible liquids
wgk
WGK 3
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