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Parteck® MXP Excipients for Hot Melt Extrusion

 
 

Two Polyvinyl Alcohol Grades Providing Excellent Performance for Solubility Enhancement and Stabilization


Poor solubility of APIs is a critical challenge in drug development. One formulation technique to address this challenge is hot melt extrusion (HME). Our Parteck® MXP range of polymers includes two polyvinyl alcohol-based excipients designed for hot melt extrusion to increase solubility and allow for stable and high drug loads for a broad range of APIs.

Parteck® MXP 3-82 Polymer

With a lower degree of hydrolysis along the PVA chain, Parteck® MXP 3-82 polyvinyl alcohol is especially beneficial in forming strong interactions with hydrophobic drug molecules – in the solid state and in solution. Due to this, Parteck® MXP 3-82 excipient has very high capabilities as a precipitation inhibitor and can maintain high levels of supersaturation for physiologically relevant timescales. As a result, Parteck® MXP 3-82 polyvinyl alcohol can provide solubility enhancement for even the most challenging molecules.

Parteck® MXP 4-88 Polymer

With a hydrolysis grade of 88%, Parteck® MXP 4-88 polyvinyl alcohol is more hydrophilic, which provides unique benefits for stabilization of certain molecules in the amorphous form. Furthermore, with a uniquely high thermal application range, Parteck® MXP 4-88 excipient can be utilized for molecules across a broad range of melting temperatures while still providing strong performance, including those classically seen as unsuitable for extrusion due to high melting points.

There’s no such thing as a one-size-fits all formulation, all APIs have individual and specific needs. With our two grades of polyvinyl alcohol for hot melt extrusion, we provide you with the possibility to fine tune your hot melt extrusion formulation to your specific API.

 
Cat. No.Product DescriptionQuantity
141464 Parteck® MXP (Polyvinyl alcohol) EMPROVE® ESSENTIAL Ph Eur,JPE,USP 1 kg, 25 kg
141544 Parteck® MXP 3-82 EMPROVE® ESSENTIAL, Ph. Eur. 1 kg, 25 kg

 

Explore and Learn More with Our Parteck® MXP Interactive Tool
Explore and learn more with our interactive tool for Parteck® MXP. Click to start exploring.
 
 
Webinar: Hot Melt Extrusion with PVA: Overcoming Solubility and Bioavailability Challenges

Webinar
Hot Melt Extrusion with PVA: Overcoming Solubility and Bioavailability Challenges

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