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04-1542 Anti-ETS1 DBD Antibody, clone 1ET 7F2

Use Anti-ETS1 DBD Antibody, clone 1ET 7F2 (Mouse Monoclonal Antibody) validated in WB to detect ETS1 DBD also known as Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1, ets protein.

Anti-ETS1 DBD Antibody, clone 1ET 7F2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: ETS1, ETS-1, p54, ETS-1 protein: ETS 1: ETS1, EWSR 2, EWSR2 UniProt Number: P14921
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04-1542
100 µL  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBMAscitesMonoclonal Antibody
      Description
      Catalogue Number04-1542
      DescriptionAnti-ETS1 DBD Antibody, clone 1ET 7F2
      Alternate Names
      • Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1
      • ets protein
      • v-ets avian erythroblastosis virus E2 oncogene homolog 1
      • v-ets avian erythroblastosis virus E26 oncogene homolog 1
      • v-ets erythroblastosis virus E26 oncogene homolog 1
      • v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
      • -ETS-1 protein, ETS 1, ETS1, EWSR 2, EWSR2
      Background InformationETS1 belongs to a family of transcription factors that regulates expression of several genes participating in extracellular matrix remodeling. Members of the ETS family regulate a variety of genes involved in stem cell development, cell senescence, and tumorigenesis. ETS1 is typically absent in healthy gastric epithelium, but expressed in many gastric carcinomas and oral squamus cell carcinomas.
      This family of transcription factors contains 2 main domains; a transactivation domain (TA), and a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes. This DNA-Binding-Domain is highly conserved among ETS family members.
      References
      Product Information
      FormatAscites
      Control
      • HL60 cell lysate
      PresentationUnpurified mouse monoclonal IgG1κ in preservative-free ascites.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-ETS1 DBD Antibody, clone 1ET 7F2 (Mouse Monoclonal Antibody) validated in WB to detect ETS1 DBD also known as Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1, ets protein.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenLinear peptide corresponding to human ETS1 DBD.
      EpitopeUnknown
      Cloneclone 1ET 7F2
      HostMouse
      SpecificityThis antibody recognizes ETS1.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteDemonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryETS transcriptions factors, such as ETS1, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM].
      Gene Symbol
      • ETS1
      • ETS-1
      • p54
      • ETS-1 protein: ETS 1: ETS1
      • EWSR 2
      • EWSR2
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Transcription factor.

      SIZE: 441 amino acids; 50408 Da

      SUBUNIT: Binds to DAXX. Interacts with UBE2I.

      SUBCELLULAR LOCATION: Nucleus.

      PTM: Sumoylated on Lys-15 and Lys-227, preferentially by SUMO2; which inhibits transcriptional activity (By similarity). & Ubiquitinated; which induces proteasomal degradation (By similarity).

      DISEASE: ETS is responsible for erythroblast and fibroblast transformation. The juxtaposition of the interferon and c-ETS-1 proto-oncogene may be involved in the pathogenesis of human monocytic leukemia.

      SIMILARITY: Belongs to the ETS family. & Contains 1 ETS DNA-binding domain. & Contains 1 PNT (pointed) domain.
      Molecular Weight~ 50 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HL60 cell lysate.

      Western Blot Analysis: 1:1,000 dilution of this antibody detected ETS1 DBD on 10 µg of HL60 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      04-1542 04053252590443

      Documentation

      Anti-ETS1 DBD Antibody, clone 1ET 7F2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-ETS1 DBD Antibody, clone 1ET 7F2 Certificates of Analysis

      TitleLot Number
      Anti-ETS1 DBD, clone 1ET 7F2 - 2459493 2459493
      Anti-ETS1 DBD, clone 1ET 7F2 - 2038643 2038643
      Anti-ETS1 DBD, clone 1ET 7F2 - 3323149 3323149
      Anti-ETS1 DBD, clone 1ET 7F2 - NG1806864 NG1806864
      Anti-ETS1 DBD, clone 1ET 7F2 - NG1947026 NG1947026
      Anti-ETS1 DBD, clone 1ET 7F2 - NRG1718894 NRG1718894
      Anti-ETS1 DBD, clone 1ET 7F2 Monoclonal Antibody 2975842
      Anti-ETS1 DBD, clone 1ET 7F2 Monoclonal Antibody 2905379