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ABE75 Anti-FOXP3 Antibody

Use Anti-FOXP3 Antibody (Rabbit polyclonal antibody) validated in WB, ICC to detect FOXP3 also known as forkhead box P3.

Anti-FOXP3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: FOXP3, IPEX, JM2 UniProt Number: Q9BZS1
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ABE75
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberABE75
      DescriptionAnti-FOXP3 Antibody
      Alternate Names
      • Forkhead box protein P3
      • Scurfin
      Background InformationFOXP3 (forkhead box P3) is a member of the FOX protein family and is thought to function as the master regulator in the development and function of regulatory T cells. As a member of the forkhead/winged-helix family of transcriptional regulators FOXP3 is believed to regulate expression through DNA binding. Mutations and deletions in the sequence encoding for FOXP3 expression lead to an inability to express FOXP3, causing an inability to regulate T cell development and leading to fatal autoimmune diseases such as IPEX and XLAAD. Conversely, other studies have shown high and wide expression of FOXP3 in several cancer cell lines and tumors, indicating that FOXP3 is involved in preventing immunity against malignant tumors.
      References
      Product Information
      FormatSerum
      HS Code3002 15 90
      Control
      • HEK293 cell lysate
      PresentationRabbit polyclonal serum containing 0.5% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-FOXP3 Antibody (Rabbit polyclonal antibody) validated in WB, ICC to detect FOXP3 also known as forkhead box P3.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 1:500 dilution from a representative lot detected FOXP3 in A431 cells.
      Biological Information
      ImmunogenLinear peptide corresponding to human FOXP3.
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].
      Gene Symbol
      • FOXP3
      • IPEX
      • JM2
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Probable transcription factor. Plays a critical role in the control of immune response.

      SUBCELLULAR LOCATION: Nucleus (Potential).

      INVOLVEMENT IN DISEASE: Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.

      SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.

      Contains 1 fork-head DNA-binding domain.
      Molecular Weight~50 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HEK293 cell lysate.

      Western Blot Analysis: 1:1,000 dilution of this antibody detected FOXP3 on 10 µg of HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE75 04053252297151