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ABF112 Anti-SPPL2a Antibody

Anti-SPPL2a Antibody is an antibody against SPPL2a for use in Western Blotting, Flow Cytometry.

Anti-SPPL2a Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: SPPL2A, IMP3, PSL2, PSEC0147 UniProt Number: Q8TCT8
ABF112
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABF112
      DescriptionAnti-SPPL2a Antibody
      Alternate Names
      • SPPL2a
      • Signal peptide peptidase-like 2A
      • SPP-like 2A
      • SPPL2a
      • Intramembrane protease 3
      • IMP-3
      • Presenilin-like protein 2
      Background InformationSignal-peptide-peptidase-like 2A (SPPL2a), a member of aspartic protease family, is an ubiquitously expressed intramembrane protease that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. It has been implicated in the proteolysis of TNF-a, Fas Ligand, and Bri2. SPPL2a exhibits about 7-0% homology with SPPL2b, however, the later is expressed primarily in adrenal cortex and mammary gland. Over-expressed SPPL2a is observed in late endosomal compartments where it co-localizes with Rab7. Its lysosomal/late endosomal sorting is dependent on a single tyrosine-based motif (Tyr498) in its cytoplasmic tail.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-SPPL2a Antibody is an antibody against SPPL2a for use in Western Blotting, Flow Cytometry.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected SPPL2a in 10 µg of Jurkat cell lysate.
      Flow Cytometry Analysis: 0.25 µg of this antibody from a representative lot detected SPPL2a in 1X10E6 Jurkat T cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of human SPPL2a.
      EpitopeCytoplasmic domain
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SPPL2A
      • IMP3
      • PSL2
      • PSEC0147
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~70/140 kDa observed. The calculated molecular weight of this protein is 58 kDa, but can be observed at ~70-140 kDa due to dimerization. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Sppl2a transfected HEK293 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected SPPL2a in 10 µg of Sppl2a transfected HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABF112 04055977136357