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MABE462 Anti-TET2 Antibody, clone hT2H 21F11

Detect Tet2 using this mouse monoclonal antibody, Anti-TET2 Antibody, clone hT2H 21F11 validated for use in Chromatin IP (ChIP), western blotting & IP.

Anti-TET2 Antibody, clone hT2H 21F11 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: TET2 UniProt Number: Q6N021
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MABE462
100 µg  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MChIP, WB, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE462
      DescriptionAnti-TET2 Antibody, clone hT2H 21F11
      Alternate Names
      • Methylcytosine dioxygenase TET2
      Background InformationMethylcytosine dioxygenase TET2 catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The function of 5-hydroxymethylcytosine is currently unclear but it may influence chromatin structure, or act as an intermediate component in cytosine demethylation. TET2 is frequently mutated in myeloproliferative disorders (MPD) or myeloproliferative neoplasms (MPN), and systemic mastocytosis. TET2 disorders also cause polycythemia vera (PV) and myelodysplastic syndrome (MDS).
      References
      Product Information
      FormatPurified
      Control
      • MOLT-4 cell lysate
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Tet2 using this mouse monoclonal antibody, Anti-TET2 Antibody, clone hT2H 21F11 validated for use in Chromatin IP (ChIP), western blotting & IP.
      Key Applications
      • Chromatin Immunoprecipitation (ChIP)
      • Western Blotting
      • Immunoprecipitation
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected TET2 in 10 µg of TF-1 cell lysate.
      Immunoprecipitation Analysis: 5 µg of a representative lot immunoprecipitated TET2 in 250 µg of HL60 RIPA cell lysate.
      Biological Information
      ImmunogenRecombinant protein corresponding to the N-terminus of human TET2.
      EpitopeN-terminus
      ClonehT2H21F11
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes the N-terminus of TET2
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • TET2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~ 260 kDa observed. The calculated molecular weight of this protein is 224 kDa, but can be observed at ~260 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MOLT-4 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected TET2 in 10 µg of MOLT-4 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABE462 04053252911767

      Documentation

      Anti-TET2 Antibody, clone hT2H 21F11 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-TET2 Antibody, clone hT2H 21F11 Certificates of Analysis

      TitleLot Number
      Anti-TET2, clone hT2H 21F11 2480977
      Anti-TET2, clone hT2H 21F11 - 3218253 3218253
      Anti-TET2, clone hT2H 21F11 - 3305921 3305921
      Anti-TET2, clone hT2H 21F11 - 3365618 3365618
      Anti-TET2, clone hT2H 21F11 - 3560115 3560115
      Anti-TET2, clone hT2H 21F11 - 3739776 3739776
      Anti-TET2, clone hT2H 21F11 - 3933214 3933214
      Anti-TET2, clone hT2H 21F11 - 3933647 3933647
      Anti-TET2, clone hT2H 21F11 - 4194302 4194302
      Anti-TET2, clone hT2H 21F11 - 4265808 4265808
      Show more

      References

      Reference overviewApplicationPub Med ID
      PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation.
      de la Rica, Lorenzo, et al.
      Genome Biol., 14: R99 (2013)  2013

      Show Abstract       		Chromatin Immunoprecipitation (ChIP)24028770 24028770

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies