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07-1441 Anti-phospho-Paxillin (Ser126) Antibody

Anti-phospho-Paxillin (Ser126) Antibody is an antibody against phospho-Paxillin (Ser126) for use in WB.

Anti-phospho-Paxillin (Ser126) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: G-proteins Gene Symbol: FLJ16691, paxillin UniProt Number: P49023
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07-1441
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-1441
      ReplacesAB3793
      DescriptionAnti-phospho-Paxillin (Ser126) Antibody
      Alternate Names
      • paxillin
      • FLJ16691
      Background InformationPaxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Serine phosphorylation of paxillin occurs in response to growth-factor activation and fibronectins. Both JNK1 and cdc2 kinases can phosphorylate serine 178 in paxillin. The mutant form of paxillin (S178A) decreases the migration of keratocytes and epithelial cells.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Pervandate treated and untreated Huvec cell lysate
      PresentationPBS (no Ca2+, no Mg2+), pH 7.3, 50% glycerol, 1 mg/mL BSA, and 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-phospho-Paxillin (Ser126) Antibody is an antibody against phospho-Paxillin (Ser126) for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugagted synthetic peptide corresponding to human Paxillin at phosphorylated Ser126.
      EpitopeSer126
      HostRabbit
      SpecificityThis antibody recognizes Paxillin phosphorylated at Ser126.
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteProven to react with human and mouse. Predicted to react with rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FLJ16691
      • paxillin
      Modifications
      • Phosphorylation
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION:: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
      SUBUNITY STRUCTURE: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 By similarity. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.
      SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cell junction › focal adhesion.
      PTM:Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.
      SEQUENCE SIMILARITIES: Belongs to the paxillin family.
      Contains 4 LIM zinc-binding domains.
      Molecular Weight68 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in pervandate treated and untreated Huvec cell lysate.
      Western Blot Analysis: 1:1,000 dilution of this antibody detected Paxillin on 10 µg of Pervandate treated and untreated Huvec cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to one year or 2-8°C for short term use from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-1441 04053252403286

      Documentation

      Anti-phospho-Paxillin (Ser126) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-phospho-Paxillin (Ser126) Antibody Certificates of Analysis

      TitleLot Number
      Anti-phospho-Paxillin (Ser126) - 2277882 2277882
      Anti-phospho-Paxillin (Ser126) - 3189752 3189752
      Anti-phospho-Paxillin (Ser126) - 3245610 3245610
      Anti-phospho-Paxillin (Ser126) - 4028548 4028548
      Anti-phospho-Paxillin (Ser126) - 4131982 4131982
      Anti-phospho-Paxillin (Ser126) - NG1944075 NG1944075
      Anti-phospho-Paxillin (Ser126) - NRG1688792 NRG1688792
      Anti-phospho-Paxillin (Ser126) -2694473 2694473

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies