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852086 Fmoc-Asp(O-2-PhiPr)-OH

Fmoc-Asp(O-2-PhiPr)-OH Novabiochem®. CAS 200336-86-3, molar mass 473.52 g/mol.

Fmoc-Asp(O-2-PhiPr)-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 200336-86-3 Molar Mass: 473.52 g/mol Hill Formula: C₂₈H₂₇NO₆
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
200336-86-3C₂₈H₂₇NO₆473.52 g/mol

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      8520860005
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          Description
          Catalogue Number852086
          Replaces04-12-1200
          Brand Family Novabiochem®
          Alternate Names
          • N-α-Fmoc-L-aspartic acid β-2-phenylisopropyl ester
          Background InformationQuasi-orthogonally-protected Asp derivative.

          The 2-PhiPr group can be removed selectively in the presence of tBu-based protecting groups by treatment with 1% TFA in DCM [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS [2] or for library synthesis. For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(Mtt) and Asp(O-2-PhiPr) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.

          This derivative has also been used in solution to prepare bicyclic helix initiating peptides [3].

          The product number for this product was previously 04-12-1200

          .

          To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
          References
          Product Information
          CAS number200336-86-3
          Hill FormulaC₂₈H₂₇NO₆
          Molar Mass473.52 g/mol
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          ApplicationFmoc-Asp(O-2-PhiPr)-OH Novabiochem®. CAS 200336-86-3, molar mass 473.52 g/mol.
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Storage class10 - 13 Other liquids and solids
          WGKWGK 2 obviously hazardous to water
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          StorageStore at -15°C to -25°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Color (visual)white to slight yellow to beige
          Appearance of substance (visual)powder
          Identity (IR)passes test
          Enantiomeric purity≥ 99.0 % (a/a)
          Purity (TLC(011A))≥ 97 %
          Purity (TLC(0811))≥ 97 %
          Assay (HPLC, area%)≥ 95.0 % (a/a)
          Solubility (1 mmole in 2 ml DMF)clearly soluble
          Assay (acidimetric)≥ 93.0 %
          Water (K. F.)≤ 2.0 %
          For TLC-Systems see our General Catalog
          Global Trade Item Number
          Catalogue Number GTIN
          8520860001 04027269088835
          8520860005 04027269088842

          Documentation

          Fmoc-Asp(O-2-PhiPr)-OH SDS

          Title

          Safety Data Sheet (SDS) 

          Citations

          Title
          • [1] C. Yue, et al. (1993) Tetrahedron Lett., 34, 323.
          • [2] F. Dick, et al. in 'Peptides 1996, Proc. of 24th European Peptide Symposium', R. Ramage & R. Epton (Eds), Mayflower Scientific Ltd., Birmingham, 1998, pp. 339.
          • [3] J. W. Taylor, et al., Poster 185 presented at the American Peptide Symposium, San Diego, 2001.