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852060 Fmoc-(FmocHmb)Ala-OH

Fmoc-(FmocHmb)Ala-OH Novabiochem®. CAS 148515-85-9, molar mass 669.72 g/mol.

Fmoc-(FmocHmb)Ala-OH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 148515-85-9 Molar Mass: 699.72 g/mol Hill Formula: C₄₁H₃₅NO₈
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852060
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
148515-85-9C₄₁H₃₅NO₈699.72 g/mol

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      Description
      Catalogue Number852060
      Replaces04-12-1127
      Brand Family Novabiochem®
      Alternate Names
      • N-α-Fmoc-N-α-(2-Fmoc-oxy-4-methoxybenzyl)-L-alanine
      Background InformationHmb protection of amide bonds has been shown to inhibit aggregation of 'difficult' peptides, thereby leading to products of increased purity [1-6]. Retention of Hmb groups on the cleaved peptide can greatly improve the solubility of protected peptide fragments [7-8] and otherwise intractable sequences [9-11]. Furthermore, using a Hmb-protected derivative for incorporation of the residue linked to the carboxyl group of Asp or Asn residues has been found to suppress formation of aspartimide and piperidide related by-products [12-14]. For a comparison of the efficiency of Hmb and pseudoprolines in preventing aggregation, see [15].

      The product number for this product was previously 04-12-1127.

      To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
      References
      Product Information
      CAS number148515-85-9
      Hill FormulaC₄₁H₃₅NO₈
      Molar Mass699.72 g/mol
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      ApplicationFmoc-(FmocHmb)Ala-OH Novabiochem®. CAS 148515-85-9, molar mass 669.72 g/mol.
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Storage class10 - 13 Other liquids and solids
      WGKWGK 2 obviously hazardous to water
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      StorageStore at +2°C to +8°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Color (visual)white to slight yellow to beige
      Appearance of substance (visual)powder
      Identity (IR)passes test
      Enantiomeric purity≥ 99.5 % (a/a)
      Purity (TLC(011C))≥ 98 %
      Purity (TLC(157A))≥ 98 %
      Assay (HPLC, area%)≥ 95.0 % (a/a)
      Water (K. F.)≤ 1.50 %
      Solubility (1 mmole in 2 ml DMF)clearly soluble
      For TLC-Systems see our General Catalog
      Global Trade Item Number
      Catalogue Number GTIN
      8520600001 04027269087685

      Documentation

      Fmoc-(FmocHmb)Ala-OH SDS

      Title

      Safety Data Sheet (SDS) 

      Citations

      Title
      • [1] T. Johnson, et al. (1993) J. Chem. Soc., Chem. Commun., 369.
      • [2] C. Hyde, et al. (1994) Int. J. Peptide Protein Res., 43, 431.
      • [3] L. C. Packman, et al. (1994) Pept. Res., 7, 125.
      • [4] T. Johnson, et al. (1994) Tetrahedron Lett., 35, 463.
      • [5] R. G. Simmonds (1996) Int. J. Peptide Protein Res., 47, 36.
      • [6] T. Johnson, et al. (1995) Lett. Pept. Sci., 1, 11.
      • [7] M. Quibell, et al. (1995) J. Am. Chem. Soc., 117, 11656.
      • [8] M. Quibell, et al. (1996) J. Chem. Soc., Perkin Trans. 1, 1227.
      • [9] M. Quibell, et al. (1994) Tetrahedron Lett., 35, 2237.
      • [10] M. Quibell, et al. (1994) J. Org. Chem., 59, 1745.
      • [11] M. Quibell, et al. (1995) J. Chem. Soc., Perkin Trans. 1, 2019.
      • [12] M. Quibell, et al. (1994) J. Chem. Soc., Chem. Commun., 2343.
      • [13] L. C. Packman (1995) Tetrahedron Lett., 36, 7523.
      • [14] J. Offer, et al. (1996) J. Chem. Soc., Perkin Trans. 1, 175.
      • [15] W. R. Sampson, et al. (1999) J. Peptide Sci., 5, 403.