419825 Sigma-AldrichHh Signaling Antagonist X, Itraconazole - CAS 84625-61-6 - Calbiochem
The Hh Signaling Antagonist X, Itraconazole, also referenced under CAS 84625-61-6, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications.
More>> The Hh Signaling Antagonist X, Itraconazole, also referenced under CAS 84625-61-6, controls the biological activity of Hh pathway. This small molecule/inhibitor is primarily used for Cell Signaling applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 14LDM Inhibitor, Oriconazole, R51211, Smo Antagonist VII, Sporanox, 14-α-demethylase Inhibitor
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 84625-61-6 | C₃₅H₃₈Cl₂N₈O₄ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 419825-250MG |
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Glass bottle | 250 mg |
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| Description | |
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| Overview | A cell-permeable, orally available triazole-class antifungal agent that, in addition to its known inhibitory activity against fungal cytochrome P450 14-α-demethylase, also acts as an effective Hh signaling inhibitor (IC50 ~ 0.8 µM against SHHN-induced Gli transcription activity in Shh-Light2 cells) in a Ptch-independent manner (IC50 ~ 0.9 µM against Ptch promoter-mediated transcription activity in murine Ptch-/- fibroblasts), presumably by binding smoothened (smo) at a site distinct from that targeted by cyclopamine (Cat. No. 239803) and SAG (Cat. No. 566660), as Itraconazole does not compete with BODIPY-cyclopamine binding, and it alters only the magnitude, but not the EC50, of SAG-induced Gli transcription activity in Shh-Light2 cells. Shown to effectively suppress Hh pathway-dependent growth of both engrafted medulloblastoma and endogenous basal cell carcinoma in mice in vivo (37.5 to 100 mg/kg/12 hr, p.o.) in a reversible manner. |
| Catalogue Number | 419825 |
| Brand Family | Calbiochem® |
| Synonyms | 14LDM Inhibitor, Oriconazole, R51211, Smo Antagonist VII, Sporanox, 14-α-demethylase Inhibitor |
| References | |
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| References | Kim, J., et al. 2010. Cancer Cell 17, 388. |
| Product Information | |
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| CAS number | 84625-61-6 |
| Form | White powder |
| Hill Formula | C₃₅H₃₈Cl₂N₈O₄ |
| Chemical formula | C₃₅H₃₈Cl₂N₈O₄ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 419825-250MG | 04055977187847 |
Documentation
Hh Signaling Antagonist X, Itraconazole - CAS 84625-61-6 - Calbiochem SDS
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Hh Signaling Antagonist X, Itraconazole - CAS 84625-61-6 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 419825 |
References
| Reference overview |
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| Kim, J., et al. 2010. Cancer Cell 17, 388. |