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496915 Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem

A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative and antiangiogenic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: NF-κB transcriptional activity
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496915
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
28957-04-2C₂₀H₂₈O₆

Pricing & Availability

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496915-5MG
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      Description
      OverviewA cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED50 = ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC50 = ~ 5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.
      Catalogue Number496915
      Brand Family Calbiochem®
      References
      ReferencesIkezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578.
      Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.
      Product Information
      CAS number28957-04-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₀H₂₈O₆
      Chemical formulaC₂₀H₂₈O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNF-κB transcriptional activity
      Primary Target IC<sub>50</sub>5 µg/ml inhibiting p65 NF-κB transcriptional activity in MT-1 cells
      Purity≥93% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSNZ8177000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      496915-5MG 04055977199871

      Documentation

      Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Oridonin, R. rubescens - CAS 28957-04-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      496915

      References

      Reference overview
      Ikezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578.
      Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-January-2017 JSW
      DescriptionA cell-permeable inhibitor of NF-κB activity that displays antiproliferative (ED50 ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis, and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages. Also inhibits p65 NF-κB transcriptional activity (IC50 ~5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number28957-04-2
      RTECSNZ8177000
      Chemical formulaC₂₀H₂₈O₆
      Structure formulaStructure formula
      Purity≥93% by HPLC
      SolubilityDMSO (10 mg/ml). Use only fresh DMSO for reconstitution.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesIkezoe, T., et al. 2005. Mol. Cancer Ther. 4, 578.
      Meade-Tollin, L.C., et al. 2004. J. Nat. Prod. 67, 2.