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CBL561 | Anti-CD24 Antibody, clone SN3

CBL561
100 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H FC, IP, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberCBL561
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD24 Antibody, clone SN3
      Alternate Names
      • Heat Stable Antigen
      • HAS
      References
      Product Information
      FormatPurified
      PresentationAffinity purified immunoglobulin by Protein G chromatography. Liquid in 1 mL of PBS, pH 7.4 containing no preservatives.
      Applications
      ApplicationAnti-CD24 Antibody, clone SN3 detects level of CD24 & has been published & validated for use in FC, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      Application NotesImmunocytochemistry on frozen tissue sections.

      Flow Cytometry: 1:50 - 1:100 per 10e6 cells in 100 μL final volume.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenGlycoproteins purified from human NALM-1 cell line.
      CloneSN3
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThe antibody reacts with the CD24 antigen a heavily glycosylated molecule that migrates as a broad band of 35-45 kDa on both reducing and non-reducing SDS gel electrophoresis. CD24 is attached to the cell membrane via a glycosyl phosphatidylinositol (GPI) anchor and is expressed at multiple stages of B cell development, beginning with the bone marrow CD34 positive pro-B cell compartment and continuing through mature surface IgM positive/IgD positive B cells. CD24 is also expressed on the vast majority of B-lineage acute lymphoblastic leukaemias, B cell chronic lymphocytic leukaemias and B cell non-Hodgkin's lymphoma. In the normal spleen, mantle zone lymphocytes are CD24 strongly positive, but germinal center cells are CD24 negative or CD24 weakly positive.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 3p26, 15q21, 15q22, 20q11.2 and Yq11.1. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.
      Gene Symbol
      • CD24
      • CD24A
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P25063 # Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
      SIZE: 80 amino acids; 8097 Da
      SUBUNIT: Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K562 and in Burkitt's lymphoma.
      SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
      TISSUE SPECIFICITY: B-cells. Expressed in a number of B-cell lines including P32/SH and Nawalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells.
      PTM: Extensively O-glycosylated.
      DISEASE: SwissProt: P25063 # Genetic variations in CD24 are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.
      SIMILARITY: SwissProt: P25063 ## Belongs to the CD24 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to 12 months from date of receipt in undiluted aliquots.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      Anti-CD24, clone SN3 - 2135101 2135101
      Anti-CD24, clone SN3 - 2376013 2376013
      Anti-CD24, clone SN3 - 2437710 2437710
      Anti-CD24, clone SN3 - 1982487 1982487
      Anti-CD24, clone SN3 - 2303948 2303948
      Anti-CD24, clone SN3 - NG1847233 NG1847233
      Anti-CD24, clone SN3 -2514989 2514989

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      The human fetal omentum: a site of B cell generation.
      Solvason, N and Kearney, J F
      J. Exp. Med., 175: 397-404 (1992) 1992

      Mostrar resumen
      1370683 1370683
      Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules.
      Fischer, G F, et al.
      J. Immunol., 144: 638-41 (1990) 1990

      Mostrar resumen
      2153173 2153173
      Follicular mantle zone cell subpopulations detected by monoclonal antibody SN3.
      Barcos, M, et al.
      Hematological oncology, 4: 251-9 1986

      3493967 3493967
      The human B cell-associated antigen CD24 is a single chain sialoglycoprotein.
      Pirruccello, S J and LeBien, T W
      J. Immunol., 136: 3779-84 (1986) 1986

      Mostrar resumen
      2939133 2939133
      New monoclonal antibodies SN3, SN3a, and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells.
      Fukukawa, T, et al.
      Exp. Hematol., 14: 850-5 (1986) 1986

      Mostrar resumen
      3489635 3489635
      Chronic lymphocytic leukemia progenitor cells carry the antigens T65, BA-1, and Ia.
      Perri, R T, et al.
      Blood, 61: 871-5 (1983) 1983

      Mostrar resumen
      6600949 6600949
      Clinical usefulness of monoclonal-antibody phenotyping in childhood acute lymphoblastic leukemia.
      Kersey, J, et al.
      Lancet, 2: 1419-23 (1982) 1982

      Mostrar resumen
      6129506 6129506

      Ficha técnica

      Cargo
      Anti-CD24, clone SN3 - Data Sheet