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AB1784P | Anti-Dopamine D1A Receptor Antibody, 4th Extracellular Domain

50 µg  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R ELISA, IHC, WB Rb Affinity Purified Polyclonal Antibody
      Catalogue NumberAB1784P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Dopamine D1A Receptor Antibody, 4th Extracellular Domain
      Product Information
      FormatAffinity Purified
      • POSITIVE CONTROL: rat striatal membranes (western blot)
      PresentationAffinity purified immunoglobulin. Liquid in PBS with 0.2% BSA and 0.05% sodium azide.
      ApplicationDetect Dopamine D1A Receptor using this Anti-Dopamine D1A Receptor Antibody, 4th Extracellular Domain validated for use in ELISA, IH & WB.
      Key Applications
      • ELISA
      • Immunohistochemistry
      • Western Blotting
      Application NotesImmunohistochemistry: 2-10 μg/mL on paraformaldehyde fixed tissue sections. D1R has been localized in various regions of the rat brain (Huang, 1992; O'Connel, 1995)

      Western blot: 1-10 μg/mL (Chemiluminescence technique). An antibody made to this peptide has been shown to detect 2 proteins of 50 and 75 kDa in solubilized hippocampal membranes. The 75 kDa band was not visible in striatum (Huang, 1992; O'Connel, 1995). Approximately 100-400 μg of protein/lane should be loaded to visualize the 75 kDa band (Huang, 1992; O'Connel, 1995) that is present in relatively small amounts.

      ELISA: 0.5-1.0 μg/mL using 1 μg/mL of control peptide per well.

      The immunogen peptide is available (Cat. No. AG266) for use in ELISA or antibody blocking studies. AG266 is not recommended for use as a western blot positive control.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenA nine amino acid peptide corresponding to the 4th extracellular domain of the rat D1A receptor. The immunogen is absolutely conserved in the mouse D1A receptor and shows 88% homology with human and 77% with porcine and bovine D1A receptors. The peptide shows no significant sequence similarity with other dopamine receptors (D1B, D2-D5).
      Epitope4th Extracellular Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificityDopamine D1A Receptor (D1R). The rat D1A receptor is a 446 amino acid, G-protein coupled transmembrane receptor protein (Monsma, 1990; Zhou, 1990; Zhou, 1992; O'Dowd, 1990). The immunogen sequence has 88% sequence similarity with human and 77% with porcine.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.
      Gene Symbol
      • DRD1
      • DRD1A
      • DADR
      • D
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P21728 # This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
      SIZE: 446 amino acids; 49293 Da
      SUBUNIT: Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD1IP.
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14 (By similarity).
      TISSUE SPECIFICITY: Detected in caudate, nucleus accumbens and in the olfactory tubercle.
      SIMILARITY: SwissProt: P21728 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information


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      Referencias bibliográficas

      Visión general referenciasAplicación EspeciePub Med ID
      Dopamine receptors in human embryonic stem cell neurodifferentiation.
      Belinsky, GS; Sirois, CL; Rich, MT; Short, SM; Moore, AR; Gilbert, SE; Antic, SD
      Stem cells and development 22 1522-40 2013

      Mostrar resumen
      Western Blotting23286225 23286225
      Modification of dopaminergic markers expression in the striatum by neonatal exposure to glutamate during development.
      S J López-Pérez, P Vergara, J P Ventura-Valenzuela, M E Ureña-Guerrero, J Segovia, C Beas-Zárate
      International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 23 335-42 2005

      Mostrar resumen
      15927757 15927757
      Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine.
      Turchan, J; Anderson, C; Hauser, KF; Sun, Q; Zhang, J; Liu, Y; Wise, PM; Kruman, I; Maragos, W; Mattson, MP; Booze, R; Nath, A
      BMC neuroscience 2 3 2001

      Mostrar resumen
      ImmunofluorescenceHuman11252157 11252157
      Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms.
      Ohara, K, et al.
      Neuropsychopharmacology, 8: 131-5 (1993) 1993

      Mostrar resumen
      8471124 8471124

      Ficha técnica

      Anti-Dopamine D1A Receptor, 4th Extracellular Domain - Data Sheet

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