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AB5847 | Anti-Glutamate Receptor 1 Antibody, phosphoSer 831

AB5847
150 µL  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5847
      Replaces05-823
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Glutamate Receptor 1 Antibody, phosphoSer 831
      Alternate Names
      • GluR1
      References
      Product Information
      FormatAffinity Purified
      Control
      • Hippocampal neurons, rat brain tissue lysates or mouse brain tissue lysate
      PresentationAffinity Purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
      Applications
      ApplicationDetect Glutamate Receptor 1 using this Anti-Glutamate Receptor 1 Antibody, phosphoSer 831 validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot and dot blots: 1:500-1:1000. The working dilution should be based on the tissue and the expected phosphorylation state.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids surrounding the phosphoSer831 of rat GluR1.
      EpitopephosphoSer 831
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Glutamate Receptor 1 [GluR1], phosphoSer831. The antibody recognizes a protein of ~100 kDa corresponding to GluR1 phosphorylated at Ser831 in rat hippocampal homogenate. Immunolabeling of the GluR1 protein is blocked by the immunogen peptide but not by the corresponding non-phosphopeptide. The immunogen sequence is 100% homologous in human and mouse.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGlutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • GRIA1
      • GluR-K1
      • GLURA
      • HBGR1
      • GluR-A
      • GluR-1
      • GLUH1
      • GLUR1
      • MGC133252
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P42261 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
      SIZE: 906 amino acids; 101506 Da
      SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2 and RASGRF2 (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Interaction with CACNG2 promotes cell surface expression (By similarity).
      TISSUE SPECIFICITY: Widely expressed in brain.
      PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
      SIMILARITY: SwissProt: P42261 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
      Molecular Weight100 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size150 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 2465128
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 -2620152 2620152
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 -2679452 2679452
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 -2713266 2713266
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 -2736652 2736652
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 -2738780 2738780
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 -2742709 2742709
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2227092 2227092
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2364150 2364150

      Referencias bibliográficas

      Visión general referenciasAplicación Pub Med ID
      Modulation of network activity and induction of homeostatic synaptic plasticity by enzymatic removal of heparan sulfates.
      Korotchenko, S; Cingolani, LA; Kuznetsova, T; Bologna, LL; Chiappalone, M; Dityatev, A
      Philosophical transactions of the Royal Society of London. Series B, Biological sciences 369 20140134 2014

      Mostrar resumen
      25225107 25225107
      GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex.
      Qiu, S; Zhang, M; Liu, Y; Guo, Y; Zhao, H; Song, Q; Zhao, M; Huganir, RL; Luo, J; Xu, H; Zhuo, M
      The Journal of neuroscience : the official journal of the Society for Neuroscience 34 13505-15 2014

      Mostrar resumen
      25274827 25274827
      Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.
      Guan, JS; Su, SC; Gao, J; Joseph, N; Xie, Z; Zhou, Y; Durak, O; Zhang, L; Zhu, JJ; Clauser, KR; Carr, SA; Tsai, LH
      PloS one 6 e25735 2011

      Mostrar resumen
      Western Blotting21984943 21984943
      Learning-induced glutamate receptor phosphorylation resembles that induced by long term potentiation.
      Shukla, K; Kim, J; Blundell, J; Powell, CM
      The Journal of biological chemistry 282 18100-7 2007

      Mostrar resumen
      Western Blotting17472959 17472959

      Ficha técnica

      Cargo
      RABBIT ANTI-GLUTAMATE RECEPTOR 1 phosphoSer831 AFFINITY PURIFIED POLYCLONAL ANTIBODY

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies